NEUROgevity™ is a next-generation nootropic and brain longevity formula combining six clinically researched bioactives across five complementary neurological pathways, targeting neuroplasticity, mitochondrial neuroprotection, synaptic membrane integrity, NGF-supported neural resilience, and foundational brain cellular signaling, designed to support focus, memory, cognitive endurance, mental clarity, mood balance, and healthy brain aging for the long term. Brain health declines across multiple simultaneous dimensions with age, chronic stress, toxin burden, and metabolic dysfunction. Neuroplasticity, the brain's ability to form new neural connections and adapt, diminishes. Nerve growth factor (NGF) activity that maintains neuron health and function declines. Neuronal membrane integrity and synaptic communication efficiency drop as phospholipid turnover slows. Mitochondria in brain cells accumulate oxidative damage and produce ATP less efficiently, reducing the energy available for cognitive demand. And the cellular signaling environment that governs synaptic function, mood balance, and neurological resilience becomes less robust with age and stress. NEUROgevity addresses each of these dimensions with precision. Dihexa supports neuroplasticity and new neural connection formation. Lion's Mane (organic fruiting body) nourishes NGF pathways for focus, memory, and neurological resilience. Uridine Monophosphate supports neuronal membrane phospholipid synthesis and synaptic communication. SalidroPure Salidroside from precision fermentation provides mitochondrial adaptogen support for cellular energy and stress resilience. MitoPrime L-Ergothioneine protects existing mitochondria from oxidative damage through its dedicated OCTN1 brain transporter. And Lithium Orotate at 300 mcg elemental, the new addition in the updated formula, provides low-dose foundational support for cellular signaling pathways, synaptic function, and balanced mood and stress response that underlies everything else. $189.99. A third-party COA for Dihexa is available on the Healthgevity product page. Refer to the product label for exact milligram supplement facts per ingredient. Key Benefits: Supports neuroplasticity and the formation of new neural connections via Dihexa Supports memory, learning capacity, and overall brain performance Supports healthy NGF pathways for focus, memory, and long-term neurological resilience via organic Lion's Mane fruiting body Supports neuronal membrane formation and synaptic communication via Uridine Monophosphate SalidroPure Salidroside from precision fermentation provides mitochondrial adaptogen support for cellular energy and cognitive stamina MitoPrime L-Ergothioneine protects neuronal mitochondria from oxidative stress via OCTN1 brain tissue transporter Dual mitochondrial support: SalidroPure for new mitochondrial energy generation, MitoPrime for existing mitochondrial protection Lithium Orotate 300 mcg elemental supports cellular signaling, synaptic function, balanced mood, and healthy cognitive function with aging Supports mental clarity, focus, and cognitive endurance during periods of physical or cognitive demand Supports neurotransmitter balance and overall cognitive vitality Five complementary neurological pathways in one formula Third-party COA available for Dihexa Updated formula with new Lithium Orotate addition What's Inside — Full Ingredient Breakdown (refer to product label for exact mg per serving): Dihexa An amino-based compound studied for its ability to support cognitive function and synaptic activity through promotion of new neural connection formation. Research indicates Dihexa supports neuroplasticity, memory, learning capacity, and overall brain performance through activity at the hepatocyte growth factor (HGF) signaling pathway, which plays a key role in synaptic density and neurological resilience. Neuroplasticity, the brain's capacity to form, strengthen, and reorganize neural connections in response to learning and experience, is foundational to healthy cognitive aging, and Dihexa's support for this process represents one of the most mechanistically novel aspects of the NEUROgevity formula. A third-party Certificate of Analysis for Dihexa is available on the Healthgevity product page. Organic Lion's Mane Extract (Hericium erinaceus, Fruiting Body) Derived from organically cultivated Lion's Mane fruiting bodies, providing the full-spectrum bioactive compounds of the mushroom rather than mycelium-on-grain preparations. Lion's Mane is the most extensively researched functional mushroom for cognitive and neurological applications, valued for its ability to support healthy nerve growth factor (NGF) pathways. NGF is the primary signaling protein responsible for the growth, maintenance, and survival of neurons, and adequate NGF activity is closely correlated with cognitive performance, memory retention, and long-term neurological resilience. Lion's Mane hericenones and erinacines from the fruiting body are the compounds documented to support NGF synthesis, complementing Dihexa's neuroplasticity activity with a distinct but convergent approach to neural health and cognitive longevity. Uridine Monophosphate A naturally occurring nucleotide and the bioavailable oral form of uridine, which crosses the blood-brain barrier and supports neuronal membrane phospholipid synthesis, synaptic communication, and healthy cognitive function. In the brain, uridine is a rate-limiting precursor for the synthesis of phosphatidylcholine and other membrane phospholipids that form the structural foundation of neuronal cell membranes and synaptic vesicles. Well-formed, fluid neuronal membranes support efficient neurotransmitter receptor function, signal transduction, and synaptic plasticity. Uridine also participates in brain energy metabolism through mitochondrial and nucleotide pathways, contributing to the cognitive energy and learning processes that form the practical outcomes of NEUROgevity's neuroplasticity and NGF support. Salidroside (as SalidroPure) The primary bioactive glycoside of Rhodiola rosea, produced through precision fermentation by SalidroPure for pharmaceutical-grade purity and consistency that eliminates the variability associated with plant-extracted Rhodiola preparations. Salidroside functions as a mitochondrial adaptogen, supporting cellular energy production, stress resilience, and mental stamina during periods of cognitive and physical demand. It activates AMPK and promotes PGC-1 alpha expression, supporting mitochondrial biogenesis, the generation of new mitochondria to meet elevated energy demands. Salidroside also supports HIF-1 alpha pathway activity and reduces oxidative stress in neural tissue, making it the formula's primary driver of mitochondrial energy generation to complement MitoPrime's mitochondrial protection. L-Ergothioneine (as MitoPrime) A rare dietary thiohistidine betaine antioxidant with a dedicated cellular transporter (OCTN1/SLC22A4) that actively accumulates it in tissues with the highest metabolic demand and oxidative exposure, including the brain, liver, red blood cells, kidneys, and mitochondria themselves. Unlike broadly distributed antioxidants, MitoPrime ergothioneine concentrates precisely where oxidative stress is highest, providing targeted mitochondrial and neuronal protection that complements SalidroPure's energy generation activity. In the brain specifically, L-Ergothioneine supports mitochondrial DNA integrity, cellular energy maintenance, healthy aging signaling, and long-term neurological resilience. MitoPrime is the highest-purity L-Ergothioneine ingredient available for supplementation. Together with SalidroPure, this creates a two-layered mitochondrial defense system: energy generation (SalidroPure) and mitochondrial protection (MitoPrime) working in parallel. Lithium (as Lithium Orotate) — 300 mcg Elemental (Updated Formula) Lithium is a naturally occurring trace mineral found in drinking water and certain plant-based foods, increasingly recognized by researchers for its role in supporting neurological resilience and healthy brain aging. Lithium Orotate is the most bioavailable oral form of lithium, delivering the mineral bound to orotic acid for enhanced cellular uptake. At 300 mcg elemental, this is a nutritional microdose that provides gentle foundational support for brain cellular signaling without the physiological impact associated with pharmacological lithium doses. Research at this nutritional level documents support for cellular signaling pathways involved in brain health, synaptic function and neuronal communication, balanced mood and stress response, and healthy cognitive function with aging. The addition of Lithium Orotate in the updated NEUROgevity formula reflects growing recognition in functional medicine and longevity research of lithium's foundational role in the neurological signaling environment that all other brain health interventions depend on. Storage Store in a cool, dry place. Keep out of reach of children. Directions Take as directed on the product label or as recommended by your healthcare professional. Consistent daily use is recommended for progressive neuroplasticity, cognitive, and brain longevity support. Consult your healthcare professional before use if pregnant, nursing, taking medications, or have a medical condition. Healthgevity NEUROgevity is a practitioner-trusted next-generation nootropic and brain longevity supplement available at SOLUDE Wellness & Beauty. It contains Dihexa (amino-based neuroplasticity compound, third-party COA available), Organic Lion's Mane Extract (Hericium erinaceus fruiting body, NGF support), Uridine Monophosphate (neuronal membrane and synaptic communication), Salidroside (as SalidroPure, precision fermentation Rhodiola rosea, mitochondrial adaptogen), L-Ergothioneine (as MitoPrime, OCTN1 brain transporter, mitochondrial protection), and Lithium (as Lithium Orotate) 300 mcg elemental (new addition, cellular signaling, synaptic function, mood) per serving. It is designed to support neuroplasticity and new neural connection formation via Dihexa, healthy NGF pathways for focus and memory via Lion's Mane, neuronal membrane formation and synaptic communication via Uridine, mitochondrial cellular energy and stress resilience via SalidroPure, existing mitochondrial oxidative protection via MitoPrime, and foundational brain cellular signaling and mood balance via Lithium Orotate. Five complementary neurological pathways. Updated formula. Single size $189.99. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.