What it is: Boluoke® is a single-ingredient, research-based oral lumbrokinase enzyme supplement from Canada RNA Biochemical, delivering 600,000 IU (26 mg, 1.6 million tPA activities) of standardized Lumbrokinase per serving in acid-resistant capsules designed to resist gastric acid and dissolve in the small intestine for maximum enzymatic bioavailability. Lumbrokinase is a multi-fraction serine protease enzyme complex extracted and purified from earthworm (Lumbricus rubellus), with over 30 years of clinical use and multiple clinical trials supporting its safety and efficacy profile since 1992. Boluoke® is the only lumbrokinase product standardized to no less than 12,000 lumbrokinase units per milligram and independently lab-tested to no less than 1.6 million tPA units per capsule. How it works: Lumbrokinase supports circulatory health through a distinct multi-enzyme fibrinolytic mechanism. Unlike nattokinase or systemic proteolytic enzymes, lumbrokinase acts on multiple points of the coagulation and fibrinolytic cascade — directly degrading fibrin clot structure, activating endogenous tissue plasminogen activator (tPA), inhibiting plasminogen activator inhibitor-1 (PAI-1), and modulating platelet aggregation — supporting a healthy fibrinolytic balance and blood fluidity within normal physiological parameters. Because Boluoke® does not significantly affect prothrombin time (PT) or activated partial thromboplastin time (aPTT), it does not meaningfully alter INR — distinguishing it from anticoagulant medications and from other lumbrokinase preparations, which may significantly affect PT or aPTT depending on their extraction method and enzyme sub-fraction composition. When to use it: Indicated for adults requiring circulatory health support, fibrinolytic balance, and healthy blood viscosity — particularly in protocols addressing hypercoagulation, poor peripheral circulation, cardiovascular inflammatory burden, or post-infectious circulatory sequelae. One to two capsules one to three times daily on an empty stomach. Discontinue at least one week prior to surgery and resume no earlier than 15 days post-surgery. Use with caution alongside anticoagulant, antiplatelet, or NSAID medications under appropriate clinical monitoring. Contraindicated in clients with active bleeding, GI ulceration, high-risk aneurysm, recent trauma, or known allergy to earthworm-derived products.