NEWEST One

NEWEST One – PN-HPT™ + Hyaluronic Acid Biorevitalisation Mastelli NEWEST One is a combined biorevitalisation treatment designed to support dermal regeneration and hydration. The formulation integrates PN-HPT™ polynucleotides, hyaluronic acid and mannitol, providing a balanced approach to skin quality improvement. It is particularly suitable for patients requiring both biological stimulation and hydration support, especially in early to moderate stages of skin ageing. KEY BENEFITS Combination of PN-HPT™ polynucleotides, hyaluronic acid and mannitol Supports fibroblast activity and dermal regeneration Improves hydration and skin elasticity Antioxidant support through mannitol Suitable for skin quality and pro-aging treatment protocols HOW IT WORKS Mastelli NEWEST One combines complementary mechanisms acting within the dermis: PN-HPT™ polynucleotides support fibroblast activation contribute to collagen and extracellular matrix regeneration promote tissue repair processes Hyaluronic acid (non-cross-linked) supports dermal hydration improves viscoelastic properties of the skin enhances extracellular environment Mannitol acts as an antioxidant helps stabilise the dermal microenvironment supports longevity of the regenerative response This combination results in progressive improvement of skin quality rather than volumetric correction. INDICATIONS Early to moderate signs of skin ageing Dehydrated and dull skin Reduced elasticity Preventive (pro-aging / longevity protocols) Maintenance after more intensive treatments PROTOCOL POSITIONING Role in treatment protocols: Combined regeneration + hydration approach Entry-level or maintenance biorevitalisation Bridge between hydration-based therapies and pure biostimulation Suitable for patients not requiring strong regenerative stimulation COMPARISON WITHIN POLYNUCLEOTIDE TREATMENTS Mastelli NEWEST One belongs to a category of biorevitalisation products based on polynucleotides, but differs in formulation and clinical positioning. Type of product Composition Primary role Pure polynucleotides (e.g. Nucleofill, Plinest) PN only Strong regenerative stimulation Combined PN formulations (e.g. NEWEST One) PN + hyaluronic acid + mannitol Balanced regeneration and hydration Hyaluronic acid skin boosters HA only Hydration and skin quality support NEWEST One is positioned as a balanced solution for patients requiring both dermal regeneration and hydration support. PRODUCT SPECIFICATION Form: solution Components: PN-HPT™ polynucleotides, hyaluronic acid, mannitol Administration: intradermal Treatment areas: face, neck, décolleté, hands Packaging: ampoules Manufacturer: Mastelli Srl (Italy) Regulatory status: CE-marked medical device COMPLIANCE This product is a CE-marked medical device intended for use by qualified healthcare professionals. It should be administered in accordance with applicable regulations and clinical practice guidelines.