BRN3A Recombinant Rabbit mAb (S-3253-25)

Product Specification Host Rabbit Antigen BRN3A Synonyms POU domain, class 4, transcription factor 1; Brain-specific homeobox/POU domain protein 3A (Brain-3A; Brn-3A); Homeobox/POU domain protein RDC-1; Oct-T1; BRN3A; RDC1; POU4F1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q01851 Clone Number S-3253-25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC-P Reactivity Hu, Ms, Rt Positive Sample mouse E14 embryo Predicted Reactivity Covering most species Purification Protein A Concentration 0.5 mg/ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied Dilution application dilution species WB 1:1000 Ms IHC-P 1:2000 Hu, Ms, Rt BackgroundBRN3A (POU4F1) is a POU-domain transcription factor that governs neuronal subtype specification and survival during development by activating pro-differentiation genes such as Runx1/3 and repressing early neurogenic factors, while in the adult it also drives cervical and myeloid oncogenesis by binding promoters of proliferation- and immune-evasion genes like IFITM1, ISG15 and BCL2L1, and its expression is boosted by the AML1/ETO fusion in t(8;21) leukaemia.