NAD+ Gold 1.7 fl oz

NAD+ Gold is a liposomal NMN and TMG formula delivering 50 mg of beta-Nicotinamide Mononucleotide (NMN), the most direct cellular precursor to NAD+, alongside 50 mg of Trimethylglycine (TMG) as a methyl donor that supports the methylation processes required for efficient NAD+ synthesis, in Quicksilver Scientific's proprietary liposomal phospholipid delivery system for rapid sublingual mucosal absorption that bypasses the gastrointestinal degradation that limits standard oral NMN and NAD+ supplement bioavailability. NAD+ (Nicotinamide Adenine Dinucleotide) is one of the most fundamentally important molecules in human biology. It functions as the central coenzyme in cellular energy production, accepting and donating electrons in the electron transport chain that generates ATP in mitochondria. It is also the required substrate for sirtuin longevity proteins (SIRT1 through SIRT7), which regulate gene expression, DNA repair, inflammatory response, metabolism, and the biological processes most directly associated with healthy aging. And it is the required cofactor for PARP enzymes, which perform emergency DNA repair when the genome is damaged by environmental stressors, radiation, oxidative stress, and the normal errors that accumulate in DNA replication. The problem is that NAD+ levels decline by approximately 50% between the ages of 20 and 50, and continue declining thereafter. This decline is driven by increased NAD+ consumption (more DNA damage and sirtuin activation demands with age), reduced synthesis efficiency, and depleted precursor availability. The consequences manifest across multiple systems simultaneously: reduced mitochondrial energy output, slower muscle recovery, impaired DNA repair, declining sirtuin activity, and the progressive accumulation of the cellular hallmarks of aging that are driven by insufficient NAD+ availability. NMN is the NAD+ precursor with the most direct and efficient pathway to cellular NAD+ synthesis. Unlike NR (Nicotinamide Riboside), which must first be converted to NMN before NAD+ synthesis can proceed, NMN enters cells directly through dedicated NMN transporters (Slc12a8) and is immediately available for conversion to NAD+ within the cell. This direct transport mechanism was confirmed in a research breakthrough that established NMN as the superior precursor choice for intracellular NAD+ replenishment. TMG is included because NAD+ synthesis through the NMN pathway consumes methyl groups, and without adequate methyl donor availability, high-dose NMN supplementation can deplete the methylation cycle. TMG provides an independent and abundant source of methyl groups through the betaine-homocysteine methyltransferase pathway, supporting the methylation demands of elevated NAD+ synthesis while simultaneously supporting healthy homocysteine metabolism. The liposomal delivery ensures that NMN reaches the bloodstream intact rather than being degraded by intestinal enzymes and gastric acid, beginning absorption in the oral mucosa during the sublingual hold for the fastest possible delivery to cells. Refrigerate upon receipt. Use within 90 days of opening. Ships with ice packs. 50 servings per 1.7 fl oz (50 mL) bottle. Vegan, non-GMO, allergen-free, sugar-free. Refrigerate upon receipt. Use within 90 days of opening. Ships with ice packs. Key Benefits: Supports NAD+ replenishment through the most direct cellular precursor pathway via NMN Supports healthy mitochondrial energy production and cellular ATP synthesis Supports SIRT1 and sirtuin longevity protein activation for gene expression, metabolism, and healthy aging Supports DNA repair mechanisms via PARP enzyme cofactor availability Supports healthy metabolism, cognitive function, and mental energy Supports physical performance, stamina, and muscle recovery Supports brain health and neurological resilience via NAD+ dependent neuronal function TMG supports methylation cycle balance during elevated NAD+ synthesis demands TMG supports healthy homocysteine metabolism as an independent methyl donor Liposomal delivery begins absorbing in the mouth for rapid, superior bioavailability NMN preferred over NR for direct cellular transport and fastest intracellular NAD+ production Refrigerate upon receipt, use within 90 days of opening Vegan, non-GMO, allergen-free, sugar-free What's Inside — Full Supplement Facts (per 1 mL / 2-pump serving): NMN (beta-Nicotinamide Mononucleotide) — 50 mg — Beta-NMN is a naturally occurring nucleotide and the most direct precursor to NAD+. It is transported directly into cells via the Slc12a8 NMN transporter, bypassing the intermediate conversion step required by NR, and is immediately available for conversion to NAD+ by the enzyme NMNAT (Nicotinamide Mononucleotide Adenylyltransferase). In the cell, NAD+ produced from NMN fuels the electron transport chain (ATP production), activates sirtuins (SIRT1-SIRT7 longevity proteins regulating gene expression and metabolism), supports PARP DNA repair enzyme activity, and participates in hundreds of additional NAD+-dependent enzymatic reactions throughout cellular metabolism. In liposomal form, NMN absorption begins in the oral mucosa, dramatically improving the speed and completeness of delivery compared to capsule NMN that must survive intestinal enzyme exposure before absorption. Trimethylglycine (TMG, as Betaine) — 50 mg — TMG is a tri-methylated glycine derivative that serves as a methyl donor through the betaine-homocysteine methyltransferase (BHMT) enzyme pathway. The inclusion of TMG alongside NMN addresses a critical biochemical consideration: NAD+ biosynthesis and sirtuin activation both consume methyl groups. Without adequate methyl donor replenishment, high-dose NMN supplementation can create a net drain on the methylation cycle, potentially elevating homocysteine and depleting S-adenosylmethionine (SAM), the universal methyl donor for hundreds of methylation reactions throughout the body. TMG at 50 mg per serving provides a complementary methyl source that supports the methylation demands of enhanced NAD+ synthesis while simultaneously supporting healthy homocysteine remethylation and liver detoxification via the BHMT pathway. This pairing of NMN with TMG reflects a clinically sophisticated approach to NAD+ supplementation that protects the broader methylation economy alongside boosting NAD+ precursor availability. Other Ingredients: Water, Glycerin, Ethanol, Phospholipids (from purified sunflower seed lecithin), Vitamin E (as Tocofersolan and Natural Mixed Tocopherols). No artificial colors, flavors, or additives. Storage Refrigerate upon receipt and keep refrigerated throughout use. Use within 90 days of opening. Store away from direct light. Ships with ice packs. Keep out of reach of children. Directions Take 2 pumps by mouth once or twice daily. Hold in mouth for 30 to 90 seconds before swallowing for maximum mucosal absorption. Repeat to desired dosage or as directed by your healthcare professional. Take on an empty stomach at least 10 minutes before meals. Best taken in the morning to align NAD+ replenishment with daytime energy demands. If pregnant or breastfeeding, consult your healthcare practitioner before use. Quicksilver Scientific NAD+ Gold is a practitioner-trusted liposomal NMN supplement available at SOLUDE Wellness & Beauty. It contains NMN (beta-Nicotinamide Mononucleotide) 50 mg and Trimethylglycine (TMG as Betaine) 50 mg per 1 mL (2-pump) serving, in a liposomal base of water, glycerin, ethanol, phospholipids (from purified sunflower seed lecithin), and Vitamin E (as tocofersolan and natural mixed tocopherols). It is designed to support NAD+ replenishment through the most direct cellular NMN precursor pathway, healthy mitochondrial energy production and ATP synthesis, SIRT1 sirtuin longevity protein activation, DNA repair via PARP enzyme cofactor activity, healthy metabolism, cognitive function, physical performance and recovery, and brain health. TMG supports methylation cycle balance during elevated NAD+ synthesis and healthy homocysteine metabolism. Liposomal delivery begins absorbing in mouth. NMN preferred over NR for direct cellular transport. Vegan, non-GMO, allergen-free, sugar-free. Refrigerate upon receipt. Use within 90 days of opening. 50 servings per 1.7 fl oz. Two pumps daily. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.