Hyalmass refers to a line of advanced aesthetic products, primarily skin boosters and hybrid fillers, developed by Maypharm Co., Ltd. of South Korea, designed for skin hydration, rejuvenation, and anti-aging purposes. These products leverage various formulations, predominantly based on high concentrations of hyaluronic acid (HA), often combined with other beneficial ingredients like niacinamide, glutathione, exosomes, and polydeoxyribonucleotide (PDRN). The Hyalmass product range includes several distinct formulations tailored for specific aesthetic outcomes: HYALMASS (Skin Booster) The original HYALMASS is described as a high-performing skin booster meticulously formulated to restore radiance from within. Key Ingredients: It utilizes ultra-pure Hyaluronic Acid for intense hydration, along with niacinamide and glutathione. Benefits: It aims to deliver deep moisturization, plump the skin, reduce dryness and fine lines, stimulate collagen and elastin for rejuvenation, enhance skin texture by smoothing uneven surfaces and refining pores, and correct pigmentation. Mechanism: Hyaluronic Acid attracts significant moisture (up to 600 times its volume), while niacinamide is recognized for its skin brightening properties, and glutathione for its anti-aging effects. Biocompatibility: The formula is designed to be biocompatible, minimizing adverse reactions. Packaging: It typically comes in a pre-filled vial of 60 cc. HYALMASS50 (Biorevitalization Injection) HYALMASS50 is a Korean biorevitalization injection notable for having one of the highest concentrations of hyaluronic acid (HA) on the market, at 50mg/2ml. Purpose: It is specifically designed for anti-aging and anti-sagging effects, providing intense hydration, plumping, restoring volume and firmness, and offering an overall lift to the skin. Mechanism: HYALMASS50 stimulates elastin to reduce skin laxity and improve overall skin texture. Crucially, it stimulates the growth of four different types of collagen through a bio-remodeling process. This bio-remodeling capability is a key differentiator, promoting structural improvement of the skin beyond simple hydration. Results: Users can expect to see tired and dull skin become firm and luminous within 3-5 days. Clinical data suggests a 12x increase in collagen and elastin, a 20% increase in skin hydration, and an 8x longer-lasting effect in the skin compared to regular HA products. Application: For facial injection, 1 mL is typically used per side of the face, with 5 injection points of 0.2 mL each, recommended twice a month. For neck injections, a 30G/13mm needle is used at a depth of 10mm/45°, with 0.2ml per point, also recommended twice a month. Target Audience: It is suitable for both men and women aged 30-50 (or above 25) with mild to moderate signs of aging, seeking to hydrate skin and improve laxity, elasticity, and fine lines. Origin: Manufactured by Maypharm in South Korea, with an expiration date of 36 months from manufacturing. Hyalmass Aqua-Exosome (Hybrid Mesotherapy Filler) Launched globally by Maypharm Co., Ltd. on December 30, 2024, Hyalmass Aqua-Exosome represents a significant advancement as a hybrid mesotherapy filler. Advanced Formulation: This product combines hyaluronic acid (1%) with exosomes (0.01mg/1ml, equivalent to 4 billion exosomes per syringe) and PDRN (0.01%). Exosomes, derived from human stem cell conditioned media and plant sources, and PDRN (polydeoxyribonucleotide) are known for their regenerative potential in aesthetic medicine, promoting cellular repair and rejuvenation. Benefits: It aims to maximize skin hydration, elasticity, and regeneration, offering a comprehensive solution that not only hydrates but also promotes long-term skin health. The formulation stimulates fibroblasts, leading to increased collagen and elastin production, improved skin elasticity, and anti-aging effects. Key Features: It comes in conveniently prefilled syringes, ensuring optimal hygiene and safety. The use of high-purity, high-molecular-weight raw materials contributes to its long-lasting efficacy. Comparison: Unlike traditional hydration fillers that primarily offer moisture, Hyalmass Aqua-Exosome provides immediate hydration while also promoting long-term skin elasticity and regeneration through its unique blend of regenerative ingredients. Usage Protocol: It can be used topically (1ml in the morning and 1ml at night), with microneedling (1 syringe at 3-week intervals), or via mesotherapy (3 times at 3-5 week intervals). Application Area: Suitable for all facial areas except around the eyes. Manufacturing: Production is supported by Beauty Factory, a Korean medical aesthetics manufacturer known for its adherence to Good Manufacturing Practice (GMP) guidelines and a rigorous 7-step quality control (QC) system. General Hyaluronic Acid Filler (CE Certified) Maypharm's Hyalmass filler, which incorporates "Hybrid Technology" and highly dense HA for long-lasting effects, obtained CE certification on April 18, 2023, allowing its entry into European and American markets. Composition: This filler is made of homogenized hyaluronic acid, Maypharm's proprietary product, ensuring high biocompatibility. It also includes lidocaine to minimize pain during the procedure. Purpose: It is designed to restore volume and smooth out wrinkles, providing temporary improvement of wrinkles and fine lines. Results and Longevity: Patients can expect immediate and noticeable improvements in the appearance of wrinkles, fine lines, and sagging skin, along with an increase in overall facial volume. The results can last for up to 12 months. Design: The product features a unique push rod and a specially designed handle to facilitate easier and more comfortable administration by practitioners. Market Presence: Before CE certification, Hyalmass fillers were already popular in South Asian markets, including Vietnam, the Philippines, Thailand, and China. Manufacturer and Quality Assurance All Hyalmass products are manufactured by Maypharm Co., Ltd., a leading innovator in medical and dermo-cosmetic products based in South Korea. Maypharm emphasizes safety and efficiency, aiming to be a highly demanded manufacturer globally. The production of Hyalmass Aqua-Exosome, for instance, is supported by Beauty Factory, which employs advanced manufacturing capabilities, including proprietary HALO manufacturing technology developed in collaboration with academic institutions like KINS Lab at Seoul National University and the Biomaterial Synthesis Lab at Sookmyung University. Beauty Factory's rigorous 7-step quality control process ensures high standards for safety and efficacy.