Recombinant Human IL-23 Protein (Powder) _ 90377ES
Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ 1. IL-23 has been shown to enhance the proliferation of memory T cells. It also stimulates IFN-γ production in NK cells, induces IL-17 production, and drives Th17-mediated responses. This Recombinant Human IL-23 is supplied in liquid form, highly active, highly pure, low endotoxin, and label free. Specification Synonyms IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF Source CHO Source Recombinant human IL-23 is composed of P40 (Ile23-Ser328) and P19 (Arg23-Pro189) subunits, which linked by GS-linker(GSGSSRGGSGSGGSGGGGSKL). Accession P29460(P40), AAG37232(P19) Molecular Weight 55.0 kDa (IL-23 single chain); 36.5 kDa (p40) & 18.5 kDa (p19) Endotoxin < 0.01 EU/μg by the LAL method. Purity > 95% as determined by SDS-PAGE and HPLC. Biological Activity Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. Formulation Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH 7.4. Tag No Physical Appearance Lyophilized Powder SEC-HPLC The purity of Human IL-23 is greater than 95% as determined by SEC-HPLC. Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. Cautions 1. Please operate with lab coats and disposable gloves,for your safety. 2. This product is for research use only.