Nucleofill Strong Plus

Nucleofill Strong Plus 1 x 2 ml – polynucleotide gel for skin laxity Nucleofill Strong Plus is supplied in a prefilled 2 ml syringe and contains purified polynucleotides, without hyaluronic acid and without lidocaine. It is the same high-viscosity formulation as Nucleofill Strong, in a 2 ml syringe instead of 1.5 ml – a third more product per unit for larger anatomical areas. It is a biostimulator, not a filler. The higher viscosity keeps the product more localised after placement than a fluid formulation would be, which is why the line is used for laxity rather than surface hydration. Use it when the problem is loss of firmness and density across a broad area. Not for volume. Product overview What it does Biostimulates the dermis. Not intended for volumisation. Manufacturer indication Overall rejuvenation and regeneration of the skin Stated actions Regeneration, antiradical action, deep moisturising, hyperoxygenation Depth Subcutaneous or intradermal only. Never intravascular. Who it suits Mature or oxidatively stressed skin where laxity and texture, not contour, are the problem Specification Product type Sterile injectable polynucleotide gel, prefilled syringe Manufacturer Promoitalia, Milan, Italy Regulatory status CE-marked medical device Active substance High molecular weight polydeoxyribonucleotide chains, highly purified Material origin Salmon-derived DNA Other constituents No proteins, no sugars, per the manufacturer. No hyaluronic acid, no anaesthetic. Presentation 2 ml prefilled syringe Intended users Practitioners trained in the injection technique How it works Promoitalia describes the polynucleotides as activating two receptor types on fibroblasts, driving type I collagen production and the maturation of fibroblasts into myofibroblasts. The manufacturer also credits the polymer with scavenging free radicals and with binding water in the extracellular matrix. Longer chains take longer to break down, so a high-viscosity gel stays in the tissue longer than a fluid one. Polynucleotides are used in regenerative aesthetic medicine to support tissue repair and skin quality through fibroblast stimulation. The gel is resorbed. The change in fibroblast behaviour is the part that is meant to persist. Treatment areas Areas listed by Promoitalia for the Nucleofill line. Face Cheeks, cheekbones, periocular area Neck Subcutaneous or intradermal Décolleté Subcutaneous or intradermal Hands Dorsal surface Body Abdomen, thighs, gluteal area Not for the eyelids or the eye socket – the manufacturer excludes both. Volume per point and per session follows the IFU. Administration Promoitalia names linear, point, cross and fan techniques, chosen according to the wrinkle type, skin condition and expected result. Safety profile Expect erythema, oedema, bruising and tenderness at the injection sites, settling over the following days. The serious event for any injectable is inadvertent intravascular injection. Promoitalia states that Nucleofill must not be injected intravascularly. Contraindications Known hypersensitivity to any component Active inflammation, infection or skin damage at the injection site Eyelids and eye socket Anything the IFU excludes The IFU in the carton carries the full list and takes precedence over this one. Choosing within the Nucleofill range Soft Plus is the soft gel for delicate areas. Medium and Strong are the 1.5 ml syringes, Medium the softer of the two. Medium Plus Hair is for the scalp. Strong Plus is the same firm gel as Strong, in 2 ml. Other polynucleotides in the catalogue The full polynucleotide range spans two source species. Mastelli’s Plinest line is trout-derived PN-HPT: Plinest for face, neck and décolleté, Plinest One for atrophic scars and stretch marks, Plinest Eye for the eye contour, Plinest Hair for the scalp. Rejuran is the salmon-derived line from PharmaResearch. Everything in the class sits under skin boosters. FAQ Does Nucleofill Strong Plus contain hyaluronic acid? No. The Nucleofill line is based on polynucleotides alone. There is no hyaluronic acid and no cross-linked gel in it. What is the difference between Nucleofill Strong and Strong Plus? Volume per syringe. Strong is supplied as 1.5 ml and Strong Plus as 2 ml. Both sit at the firm end of the range. Can it be used around the eyes? Promoitalia excludes injection into the eyelids and the eye socket for Nucleofill. Nucleofill Soft Plus is the formulation the manufacturer directs at delicate areas. Does it contain an anaesthetic? No. There is no lidocaine in the syringe. Which body areas does the manufacturer list? Neck, decollete, face including cheeks and cheekbones, the back of the hands, the abdomen, thighs and gluteal area. {“@context”:”https://schema.org”,”@type”:”FAQPage”,”mainEntity”:[{“@type”:”Question”,”name”:”Does Nucleofill Strong Plus contain hyaluronic acid?”,”acceptedAnswer”:{“@type”:”Answer”,”text”:”No. The Nucleofill line is based on polynucleotides alone. There is no hyaluronic acid and no cross-linked gel in it.”}},{“@type”:”Question”,”name”:”What is the difference between Nucleofill Strong and Strong Plus?”,”acceptedAnswer”:{“@type”:”Answer”,”text”:”Volume per syringe. Strong is supplied as 1.5 ml and Strong Plus as 2 ml. Both sit at the firm end of the range.”}},{“@type”:”Question”,”name”:”Can it be used around the eyes?”,”acceptedAnswer”:{“@type”:”Answer”,”text”:”Promoitalia excludes injection into the eyelids and the eye socket for Nucleofill. 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