4-Hydroxytamoxifen solution, 5 mg/ml in ethanol: isopropanol (95:5)
4-Hydroxytamoxifen is a metabolite of tamoxifen, a SERM that acts as an agonist or antagonist in various tissues. It inhibits specific estrogen receptors and shows anticancer properties.
- 4-Hydroxytamoxifen induces autophagy and vacuole formation and degrades KRAS in cancer cells.
- In cardiac myocytes, 4-Hydroxytamoxifen decreases Ca2+ amplitude, slowing relaxation and decreasing contractility.
- 4-Hydroxytamoxifen is a potent inhibitor of the mitochondrial permeability transition.
Specifications
- Synonyms
- Afimoxifene, 4-OHT, cis/trans-4-Hydroxytamoxifen, (E/Z)-4-Hydroxytamoxifen, HTMX, 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
- Purity
- ≥98% (HPLC)
- Appearance
- Colourless liquid
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