ACUTIN 20mg (containing the active ingredient isotretinoin) is a highly effective, systemic retinoid (vitamin A derivative) used primarily to treat severe, recalcitrant nodular acne that has failed to respond to conventional therapies, including antibiotics. It is often considered the most effective treatment for severe acne, capable of producing long-term remission. This is a prescription product. We require a valid prescription by a licensed physician.