DUTCH Complete + DNA Hormones

DUTCH Complete The DUTCH Complete provides a comprehensive assessment of sex hormone metabolism and adrenal function using dried urine sampling across the day. The panel measures parent hormones and downstream metabolites alongside the diurnal pattern of free cortisol and markers of melatonin metabolism, offering detailed insight into hormone production, clearance and circadian rhythm patterns. In women, this type of profiling may be clinically relevant in contexts such as menstrual irregularities, premenstrual symptoms, menopausal transition, sleep disturbance or hormone replacement therapy monitoring. In men, it may support evaluation of fatigue, changes in mood or libido, altered body composition or age-related shifts in androgen balance. Inclusion of additional organic acid and oxidative stress markers enables broader consideration of metabolic and lifestyle factors that may influence hormonal regulation. Results are interpreted alongside clinical presentation, lifestyle patterns and other laboratory findings. Reviewing hormone metabolite patterns over time can help practitioners build a more personalised picture of endocrine function and support discussions around nutrition, lifestyle and therapeutic strategies. Indications Women Fatigue or low energy: Persistent tiredness that may relate to adrenal or sex hormone imbalance. Low mood or depression: Changes in emotional wellbeing or motivation linked to hormonal fluctuations. Reduced libido: Decline in sexual desire or satisfaction possibly influenced by oestrogen or testosterone levels. Premenstrual symptoms: PMS, irritability or mood swings occurring before menstruation. Menopausal changes: Hot flushes, sleep disruption or other signs of hormonal transition. Weight gain: Gradual or unexplained weight increase that may relate to changes in metabolism or hormone balance. Men Fatigue or low energy: Ongoing tiredness or reduced stamina possibly linked to hormone levels. Low mood or depression: Persistent low mood or lack of motivation that may correspond with testosterone or cortisol imbalance. Reduced sex drive: Lower libido or sexual performance potentially influenced by changes in androgen activity. Sleep disturbance: Difficulty falling asleep or staying asleep associated with cortisol rhythm. Hair loss: Gradual thinning or changes in hair pattern possibly linked with hormone variation. Weight gain: Increased abdominal or overall body weight that may reflect hormonal shifts. Practical Specimen requirements: Dried urine sample Average processing time: 18 ±4 days Restriction: This test is not available for patients below 12 years of age. DNA Hormones DNA Hormones is a comprehensive nutrigenetic test analysing and reporting on metabolism and detoxification of sex hormones. The DNA Hormones test analyses and reports on gene variants that have been shown to have an impact on sex steroid metabolism and biotransformation, affecting male and female health. DNA Hormones is an upgrade of, and will replace, the DNA Oestrogen test. The report offers personalised diet, lifestyle and hormone interventions to support relevant pathways and help you achieve and maintain optimal hormonal health and resilience and extended healthspan. Clinical value Research has shown that hormonal imbalances can occur due to an increased lifetime exposure to an unsuitable environment (e.g. high oestrogen exposure, increased BMI, carcinogens, sedentary behaviour). This, together with an intrinsic imbalance, due to genetic variation, is a strong risk factor for the development of various hormone-related conditions, affecting both men and women. Depending on the stage in an individual’s lifecycle, environmental exposures and genetic variants carried, certain hormonal biosynthesis, degradation and biotransformation pathways might be preferred. This increases risk for altered sex hormone metabolite ratios as well as imbalance in redox status. These alterations have been linked to predisposition for hormone related disorders including: Endometriosis and polycystic ovarian syndrome (PCOS) Subfertility Earlier onset of, and heightened symptoms in menopause Bone health disorders Thrombosis Hormone-related cancers such as breast, ovarian and prostate cancer The test should be considered for those who are suffering from, or have a family history of, any hormone related disorder or experiencing symptoms that might be related to imbalanced hormone metabolism. It is also beneficial for anyone taking/considering hormone therapy (contraceptive or replacement therapy) for insights into potential clotting risk and to ensure detoxification pathways are optimally supported.