VODA DERM NMN System ( Nad - 1 Vial )

NMN Signal Starter System | 3 mL × 1 Vial / Box | Republic of Korea NMN Signal. Awakened Vitality. VODA DERM NMN System is a precision-designed NMN conditioning system for the first step of skin vitality care. Built around the NMN to NAD+ vitality pathway, it connects four sequential mechanisms — Activate, Communicate, Energize, and Refine — into one coherent signal system. This is not a simple NMN ampoule. VODA DERM NMN System is designed to activate and shape the flow of skin vitality through a structured multi-ingredient approach, targeting tired-looking, dull, and low-vitality skin conditions. A connected system for awakened skin vitality. Why NMN Signal Care? When skin condition declines, skin begins to look tired. The first step of skin vitality care begins not with simple supplementation, but with preparing the flow of skin condition. VODA DERM NMN System is designed to support NMN-based skin vitality signals for tired-looking skin conditions. Signs that indicate a vitality signal is needed: Low Vitality: Skin condition that needs a vitality signal Dull Impression: Skin that needs a clearer, refined look Uneven Texture: Skin that appears unbalanced and less refined Reduced Elasticity: Skin that needs an energized-looking impression Why NAD+ Signal Matters NAD+ is an essential coenzyme governing cellular energy metabolism and skin homeostasis. However, as we age, skin NAD+ levels deplete rapidly, acting as a fundamental cause of reduced skin vitality. Research shows NAD+ levels fall from 100% at newborn to approximately 32% in young adults (~20s), and further to approximately 13% by middle age (~40–60s). Source: Peluso A, et al. Age-Dependent Decline of NAD+. Nutrients 2022;14(1):101. PMC8747183. Core Functions of NAD+ Mitochondria — Cellular Energy Metabolism Supports mitochondrial energy metabolism to awaken the energy flow of skin cells. PARP1 — DNA Repair Pathway Acts as a key substrate for PARP in DNA repair pathways, activating the skin's defense against oxidative stress. SIRT1 — Sirtuin Activation (Anti-Aging Core Pathway) Acts as an essential cofactor in aging-related sirtuin pathways, supporting skin density and resilience against intrinsic aging. The above descriptions are based on published scientific studies related to NMN and NAD+ biology. They refer to the general characteristics of the ingredient and do not represent the direct clinical efficacy of the finished product. 4-Step NMN Signal Conditioning System A 4-step signal system designed to begin with NMN and shape the flow of skin vitality. VODA DERM NMN System is designed around NMN, connecting the NAD+ pathway, Grape Phyto-Exosome, Energy Co-Factors, and Bio-Polypeptide refinement as one precision system designed to activate, communicate, energize, and refine the flow of skin vitality. STEP 01 ACTIVATE NMN → NAD+ Vitality Pathway Supports a skin vitality pathway from NMN to NAD+. STEP 02 COMMUNICATE Grape Phyto-Exosome Signal Grape-derived Phyto-Exosome support for skin conditioning signals. STEP 03 ENERGIZE Energy Co-Factor Support Supportive design with Coenzyme A, Thiamine Diphosphate, and Inositol. STEP 04 REFINE Bio-Polypeptide Conditioning Skin impression refinement with 5 types of sh-Polypeptides. Step 01 — ACTIVATE: NMN → NAD+ Vitality Pathway A skin vitality pathway from NMN to NAD+. Why NMN? NAD+ is a key coenzyme that drives the vitality flow of skin cells. NMN is one of the most direct key precursors for NAD+ biosynthesis, converted into NAD+ in a single step by NMNAT enzymes to ignite skin vitality. VODA DERM NMN System is designed around the NMN → NAD+ pathway to shape an awakened vitality flow for tired-looking skin conditions. The Synergy of NMN & NAD+ Combining direct NAD+ support with NMN-driven intracellular synthesis for immediate and sustained skin vitality. Pathway Role Key Message NAD+ Direct Support Immediate support Supports direct NAD+-related vitality signaling NMN-Driven Replenishment Sustained support Supports intracellular NAD+ biosynthesis NAD+ + NMN Dual System Combined support Designed for immediate + sustained vitality support Research indicates that combining direct NAD+ supply with NMN-driven biosynthesis, acting through complementary routes including the CD38/NAD+/SIRT1 axis, supports a greater cellular NAD+ response than either ingredient alone. Source: Kang S, et al. Cells 2024;13(21):1799; Conlon N, Kang S. Nutrients 2023;15(2):445. NMN → NAD+. The first pathway of awakened vitality. Step 02 — COMMUNICATE: Grape Phyto-Exosome Signal Optimization of Intercellular Signaling. VODA DERM has established an active delivery system utilizing grape callus-derived Phyto-Exosomes to improve the transdermal permeability of high-purity NMN. This system functions as an intercellular signaling mediator to drive homeostasis in the dermal microenvironment. Distinctive Features of Phyto-Exosomes SIZE — Nano-Scale 50–150 nm natural lipid bilayer structure, optimized for skin barrier penetration. CARGO — Bioactive Signal Encapsulates proteins and antioxidant phytochemicals to directly activate cellular signal networks. SAFETY — Low Immunogenicity 60–80% lower immunogenicity compared to mammalian exosomes, eliminating immune rejection risk. SOURCE — Grape Callus Plant stem cell extraction technology concentrates active ingredients into exosomes, maximising absorption. How Phyto-Exosomes Work Step 1 — Skin Cell Internalization: Exosomes are absorbed into skin cells, delivering their contents directly inside the cells. Step 2 — Signal Activation & Regeneration Promotion: miRNA, proteins, and NMN activate cellular signalling, promoting regeneration and skin vitality. Grape Phyto-Exosome. Precision delivery for deeper signal activation. Step 03 — ENERGIZE: Energy Co-Factor Support Fuel the flow. Complete the signal. VODA DERM NMN System adds co-factor support to sustain the NMN → NAD+ vitality pathway. Rather than relying on NMN alone, the formula incorporates key metabolic co-factors that work alongside the NAD+ pathway to maintain cellular energy balance. Coenzyme A — Energy-Related Conditioning Support Supports energy-related conditioning and plays a central role in cellular metabolic processes. Thiamine Diphosphate — Metabolic Co-Factor A metabolic co-factor concept ingredient that supports key energy metabolism pathways. Inositol — Balanced Skin Condition Support Supports a balanced skin condition and contributes to a stable cellular environment. Sodium Gluconate — Formula Balance Support Supports overall formula balance and helps maintain a stable product environment. Fuel the flow. Complete the signal. Step 04 — REFINE: Bio-Polypeptide Conditioning 5-Polypeptide Complex for skin impression refinement. Following cellular activation and energy supply via NMN, the robust reorganisation of the epidermal and dermal physical structures is essential. The REFINE stage utilises 5 types of recombinant peptides (sh-Polypeptides) to restore the compromised skin barrier and matrix architecture, supporting the formation of a smooth skin condition. sh-Polypeptide-7 — hGH Fragment Cell growth & regeneration signal. sh-Polypeptide-5 — TGF-β3 Analog Cell differentiation & ECM remodelling. sh-Polypeptide-4 — SCF Analog Stem cell activation & epidermal renewal. sh-Polypeptide-2 — IGF-1 Analog Collagen & elastin synthesis support. sh-Polypeptide-16 — BMP-2 Analog Dermal structure refinement & signalling. Areas of Skin Quality Addressed: Regeneration Texture Collagen Skin Barrier Anti-Aging 5 recombinant polypeptides. One refined skin impression. Recommended For Skin that needs a vitality signal — from the inside out. Low skin vitality — skin that looks tired and lacks radiance Dull skin impression — skin that needs a clearer, more refined look Uneven texture — skin that appears unbalanced and less refined Reduced elasticity — skin that needs an energised-looking impression Skin conditions associated with age-related NAD+ decline Patients seeking a structured skin vitality programme Recommended Application Protocol Overview Treatment Area Entire face, avoiding the eye area Methods MTS / Dermashine / Manual Injection Recommended Course 3 sessions, 3–5 week intervals Dosage Approx. 3 mL per face (per session) Method 1 — MTS (Micro-Needling) MTS creates micro-channels on the skin surface to maximise absorption of active ingredients across the epidermal–dermal layers, and stimulates collagen production through the natural healing process. Injection Depth Epidermis to dermis 0.25 – 0.5 mm Dosage Approx. 3 cc per face Procedure Step 1 Divide the face into zones (forehead, cheeks, nose, chin) Procedure Step 2 Apply adequate amount of NAD/NMN ampoule to each zone Procedure Step 3 Roll/stamp device in horizontal, vertical, and diagonal directions Procedure Step 4 After treatment, apply remaining ampoule once more and gently pat to absorb Method 2 — Dermashine Dermashine uses 9-pin / 5-pin multi-needles to uniformly and rapidly inject product across the entire face. Faster procedure with less pain and bruising compared to manual injection. Injection Depth Dermis layer 1.0 – 1.5 mm Dosage Approx. 3 cc per face (may vary by area, technique, and skin condition) Procedure Step 1 Set injection depth and desired volume on the device Procedure Step 2 Press injector fully against skin and inject through multi-needles Procedure Step 3 Repeat at consistent intervals across the treatment area for even distribution Method 3 — Manual Injection Manual injection involves the physician precisely targeting the dermis with a syringe. Most effective for localised areas such as eye corners, mouth lines, and nasolabial folds, with minimal product loss. Injection Depth Dermis layer 0.8 – 1.2 mm Dosage Approx. 2 cc – 3 cc per face / minimal loss due to precise injection Procedure Step 1 Enter at a 10–15 degree angle to the skin surface, very shallow Procedure Step 2 Treat in a grid pattern with 0.5 cm spacing Key Point Confirm small papules form densely on the skin surface as you inject Product Specifications NMN 100ppm NMN Concentration NAD+ 100ppm NAD+ Concentration 3 mL Volume / Vial 1 vial Per Box Product VODA DERM NMN System Category NMN Signal Starter System Brand VODA DERM by Celset Packaging 3 mL × 1 Vial / 1 Box Main Ingredients NMN (100 ppm), NAD+ (100 ppm) Origin Republic of Korea Storage Store in a cool, dry place away from direct sunlight For registered practitioners only. This product is intended for professional use by qualified and licensed practitioners. Not for retail sale. Results disclaimer: Images are for reference only and do not represent the results of any specific product. Actual results may vary depending on the individual. Scientific references: Descriptions based on published scientific studies related to NMN and NAD+ biology. They refer to the general characteristics of the ingredient and do not represent the direct clinical efficacy of the finished product.