Rejuran Rejuvenation PN

Rejuran Rejuvenation with PN 1 x 2 ml – Salmon Polynucleotide Injectable for Skin Regeneration Rejuran Rejuvenation with PN is the reference polynucleotide injectable of PharmaResearch’s Rejuran range, designed to improve skin quality through dermal regeneration rather than volumisation. The 2% salmon-derived PN formulation is used for ageing, photodamaged and dehydrated skin requiring progressive tissue renewal. Supplied as a 2 ml pre-filled syringe, it is the export designation of the product marketed in Korea as Rejuran Healer, and the format intended for larger treatment fields: full face, neck, décolleté and hands. Key features ✓ CE-marked injectable medical device ✓ 2% salmon-derived polynucleotide ✓ Salmon-derived, no human-origin components ✓ 1 x 2 ml pre-filled syringe ✓ Intradermal placement ✓ No hyaluronic acid, no volumising effect Product overview Feature Value Category Polynucleotide regenerative injectable Active substance Sodium polynucleotide (PN), 2% DNA source Salmon Mechanism Dermal regeneration, matrix remodelling Injection depth Superficial to mid dermis Technique Microdroplet or linear threading, per IFU Face Cheeks, perioral area, forehead, full-face revitalisation Body Neck, décolleté, back of hands Patient profile Thin, dehydrated or photodamaged skin Sessions 3-4, approximately 2-4 weeks apart Results appear Progressively across the course Final assessment 4-8 weeks after last session Maintenance Every 6-12 months Downtime Minimal Mechanism Polynucleotides are high-molecular-weight deoxyribonucleotide polymers. As a product class they are described in the clinical literature as supporting fibroblast activity and extracellular matrix remodelling, with the injected gel forming a temporary dermal scaffold that is progressively resorbed. The gel resorbs. The remodelled matrix remains. There is no immediate correction. Any change visible on the day of treatment reflects the injected gel and associated oedema, both of which resolve within one to three days. Improvement in density, elasticity, pore appearance and fine surface lines develops across the course, with outcome assessed four to eight weeks after the final session rather than at the next scheduled visit. Treatment areas Face: full-face revitalisation, cheeks, perioral area, forehead, fine surface lines, enlarged pores. Body: neck, décolleté, back of hands. The 2 ml format suits large treatment fields and thin, photodamaged or chronically dehydrated skin. Patients presenting for contour correction belong in HA filler protocols , and those with diffuse deep collagen deficit in a biostimulator protocol . Within the salmon-derived class, Nucleofill Medium shares the same 2% concentration; Croma PolyPhil is the trout-derived alternative. For the periorbital region, a lower-concentration formulation such as Croma PolyPhil Eye is the appropriate selection. Rejuran range Feature Rejuran Rejuvenation with PN Rejuran I Rejuran HB Plus Composition PN only PN only PN + HA + lidocaine PN concentration 2% 1% 2% Volume 2 ml 1 ml 1 ml Primary area Full face, neck, décolleté Periorbital Face, neck, décolleté Objective Dermal regeneration Thin-skin regeneration Regeneration with hydration Anaesthetic in product No No Yes Administration Depth: superficial to mid dermis. Injection depth is an important factor in the visibility and persistence of post-injection papules. Technique: microdroplet or linear threading, with point spacing and volume per point according to IFU and injector preference. Needle or cannula: selected by area and technique; see the available cannulas and needles . Anaesthesia: the product contains none; topical anaesthesia is applied at the practitioner’s discretion. Safety profile Common reactions are injection papules, erythema, oedema, bruising and tenderness at the injection site, typically resolving within one to three days. Less commonly reported: prolonged papule persistence following excessively superficial placement, injection-site infection, post-inflammatory hyperpigmentation and hypersensitivity to fish-derived material. Contraindications The following are general considerations and do not replace the product-specific Instructions for Use. Known hypersensitivity to any component of the product; review any history of hypersensitivity to fish-derived materials Active infection, inflammation or skin lesions at the injection site Pregnancy and breastfeeding Patients under 18 years of age Specification Active substance Sodium polynucleotide (PN), 2% Volume 2 ml per pre-filled syringe Pack 1 syringe + package insert Anaesthetic None Storage As specified in the manufacturer’s IFU. Protect from light. Do not freeze. Shelf life 17 months, unopened Manufacturer PharmaResearch Co., Ltd. Classification CE-marked injectable medical device, MFDS registered Availability Licensed medical professionals only FAQ Is this the same product as Rejuran Healer? Rejuran Rejuvenation with PN is the 2 ml polynucleotide formulation supplied for export markets and is commonly associated with the product known in Korea as Rejuran Healer. Check labelling and IFU for the specific market. How does it differ from an HA skin booster? Hyaluronic acid boosters act primarily through water binding. A polynucleotide injectable is directed at the dermal matrix, and the result develops progressively across a course rather than after a single session. How many sessions are needed? Three to four sessions spaced two to four weeks apart, with maintenance every six to twelve months. Outcomes after an incomplete course may not reflect the result expected from the full protocol. When is Rejuran I the better choice? In the periorbital area. The lower-concentration formulation is developed for thin eyelid skin, where the 2 ml format is not the appropriate viscosity or volume for intradermal placement. Can it be combined with other injectables? Sequentially, yes. Same-session combination with fillers or biostimulators makes both results and adverse events harder to attribute. Complete the course, assess, then introduce the second product.