Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.† Methylation is a chemical process that happens in every cell of your body and it’s essential for: Making energy Repairing cells Regulating gene expression Nutrients to Support Methylation TMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.† “The changes in DNA methylation across a lifespan is a hallmark of aging.” (1) Aging and Methylation Issues Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.† "Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease." ⑵ Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.† NAD+ Precursors and Methylation Pathways When taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.† “High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4) It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD+ precursors are often supplemented with TMG and other compounds that support methylation pathways.† Acid Resistant Enteric Capsules ​​Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.