cFluor® BYG781 Anti-Human CD21 (LT21)
type: Product
description: The mouse monoclonal antibody clone LT21 binds to an extracellular epitope of human CD21, a 145 kDa type I transmembrane glycoprotein also known as complement receptor 2 (CR2), C3d receptor (C3dR), and EBV receptor. CD21 is expressed on mature B lymphocytes, follicular dendritic cells, a subset of T lymphocytes, and some epithelial cells, but is absent on immature B cells. CD21 functions as a receptor for complement fragments C3d, C3dg, and iC3b, which remain covalently attached to complement-activating surfaces and antigens. On the B cell surface, CD21 associates with CD19, CD81, and Leu-13 to form a large co-receptor signaling complex that amplifies B cell receptor activation in response to complement-opsonized antigens. CD21 also serves as the obligate receptor for Epstein-Barr virus (EBV), mediating viral binding and entry into B lymphocytes via interaction with the viral glycoprotein gp350/220. Additional roles for CD21 include uptake and retention of immune complexes, survival of memory B cells, and maintenance of the humoral response to T-dependent antigens. Clone LT21 has been validated for flow cytometric analysis of human peripheral blood leukocytes and has been reported to cross-react with canine and porcine CD21. PRODUCT DETAILSClone: LT21Specificity: CD21Reactivity: Human, Dog, PigFormat: cFluor® BYG781Isotype: Mouse IgG1Tested Dilution: 5 µl/TestApplication: Flow CytometryStorage: 2-8°C protected from light. Do not freezeFormulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA)Data Sheets: TDS | SDS RECOMMENDED USAGEEach lot of this antibody is quality control tested using flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 μL per 1 million cells in a staining volume of 100 μL. If whole blood is analyzed, then use 5 μL per 100 μL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. Please bri…
brand: Cytek Biosciences
sku: R7-21607
additional property: Size
  type: PropertyValue
  value: 100 Tests, 25 Tests
offers: AggregateOffer
  low price: 175.00
  high price: 375.00
  price currency: USD
  offer count: 2
  offers: Offer
    price: 375.00
    price currency: USD
    availability: https://schema.org/InStock
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    sku: R7-21607
  offers: Offer
    price: 175.00
    price currency: USD
    availability: https://schema.org/InStock
    item condition: https://schema.org/NewCondition
    sku: R7-21608

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