Rejuran HB PLUS

Rejuran HB Plus 1 ml – Polynucleotide and Hyaluronic Acid Hydrobooster with Lidocaine Rejuran HB Plus is the hybrid formulation of PharmaResearch’s Rejuran range, combining salmon-derived polynucleotides with hyaluronic acid and lidocaine. Hyaluronic acid contributes to early hydration, while the polynucleotide fraction supports progressive tissue regeneration. Supplied as a 1 ml pre-filled syringe, it is the Rejuran format for dehydrated, dull and textured skin, and the only one containing an anaesthetic – which, according to the manufacturer, is intended to reduce procedural discomfort. Key features ✓ CE-marked injectable medical device ✓ Polynucleotide and hyaluronic acid in one syringe ✓ Lidocaine hydrochloride included ✓ Salmon-derived, no human-origin components ✓ 1 ml pre-filled syringe ✓ Superficial dermal placement Product overview Feature Value Category Hybrid PN and HA hydrobooster Active substances Sodium polynucleotide, sodium hyaluronate Anaesthetic Lidocaine hydrochloride DNA source Salmon Mechanism Dermal regeneration with hydration Injection depth Superficial dermis Technique Microdroplet or linear threading, per IFU Face Cheeks, perioral area, forehead, full-face revitalisation Body Neck, décolleté, back of hands Patient profile Dehydrated, dull or textured skin Sessions 3-4, approximately 4 weeks apart Results appear Hydration early, skin quality across the course Maintenance Every 4-6 months Downtime Minimal Mechanism Polynucleotides are high-molecular-weight deoxyribonucleotide polymers. As a product class they are described in the clinical literature as supporting fibroblast activity and extracellular matrix remodelling, with the injected gel forming a temporary dermal scaffold. The hyaluronic acid fraction binds water in the same plane. Hyaluronic acid contributes to early hydration. The polynucleotide fraction supports progressive regeneration. The early effect is hydration and improved surface smoothness rather than structural change; it is not a volumising product and does not correct contour. Improvement in texture, pore appearance and fine surface lines develops across a course of three to four sessions, assessed once the course is complete. Treatment areas Face: full-face revitalisation, cheeks, perioral area, forehead, dull and dehydrated skin, enlarged pores. Body: neck, décolleté, back of hands. The formulation applies where dehydration, dullness and early textural change are the presenting problems. Patients presenting for contour correction belong in HA filler protocols , and those with diffuse deep collagen deficit in a biostimulator protocol . Within the same hybrid class, Croma PolyPhil Next combines PN-HPT with non-crosslinked hyaluronic acid in a 2 ml format. Where the objective is regeneration without a hydrating fraction, Nucleofill Medium is the pure polynucleotide reference point; where it is HA bioremodelling alone, Profhilo H+L works through a different mechanism. Rejuran range Feature Rejuran HB Plus Rejuran Rejuvenation with PN Rejuran I Composition PN + HA + lidocaine PN only PN only PN concentration 2% 2% 1% Volume 1 ml 2 ml 1 ml Primary area Face, neck, décolleté Full face, neck, décolleté Periorbital Objective Regeneration with hydration Dermal regeneration Thin-skin regeneration Anaesthetic in product Yes No No Administration Depth: superficial dermis. Injection depth is an important factor in the visibility and persistence of post-injection papules. Technique: microdroplet or linear threading, with point spacing and volume per point according to IFU and injector preference. Needle or cannula: selected by area and technique; see the available cannulas and needles . Anaesthesia: lidocaine is included in the formulation. Review the patient’s history of hypersensitivity to lidocaine or other amide-type local anaesthetics before use. Safety profile Common reactions are injection papules, erythema, oedema, bruising and tenderness at the injection site, typically resolving within one to two days. Less commonly reported: prolonged papule persistence following excessively superficial placement, injection-site infection, post-inflammatory hyperpigmentation and hypersensitivity to fish-derived material or to lidocaine. Contraindications The following are general considerations and do not replace the product-specific Instructions for Use. Known hypersensitivity to any component of the product; review any history of hypersensitivity to fish-derived materials Known hypersensitivity to lidocaine or other amide-type local anaesthetics Active infection, inflammation or skin lesions at the injection site Pregnancy and breastfeeding Patients under 18 years of age Specification Active substances Sodium polynucleotide, sodium hyaluronate Anaesthetic Lidocaine hydrochloride Volume 1 ml per pre-filled syringe Pack 1 syringe + package insert Storage As specified in the manufacturer’s IFU. Protect from light. Do not freeze. Shelf life 17 months, unopened Manufacturer PharmaResearch Co., Ltd. Classification CE-marked injectable medical device, MFDS registered Availability Licensed medical professionals only FAQ How does it differ from Rejuran Healer? Rejuran Healer, supplied for export as Rejuran Rejuvenation with PN, is a 2 ml polynucleotide-only syringe. HB Plus is a 1 ml formulation combining polynucleotide with hyaluronic acid and lidocaine. How does it differ from Rejuran I? Rejuran I is a lower-concentration polynucleotide formulation for the thin skin of the periorbital area. HB Plus is a hybrid formulation with hyaluronic acid, intended for the face, neck and décolleté. Is a topical anaesthetic still required? The lidocaine content may reduce the need for topical anaesthesia in selected patients. Practice varies, and topical anaesthetic remains an option at the practitioner’s discretion. How many sessions and how often? Three to four sessions approximately four weeks apart, with maintenance every four to six months. Outcomes after an incomplete course may not reflect the result expected from the full protocol. Can it be combined with other injectables? Sequentially, yes. Same-session combination with other boosters or fillers makes both results and adverse events harder to attribute. Complete the course, assess, then introduce the second product.