AICAR (Acadesine / AICA-Riboside)

✅ Canonical small-molecule AMPK activator (cell-permeable AMP-mimetic via ZMP) ✅ Drives insulin-independent glucose uptake into skeletal muscle ✅ Suppresses hepatic gluconeogenesis, de-novo lipogenesis, cholesterol synthesis ✅ Published ‘exercise mimetic’ phenotype (Narkar et al. 2008, Cell) ✅ Reference compound for AMPK pharmacology — MW 258.23, CAS 2627-69-2 AICAR contains 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside research compound.