Calcium D-Glucarate

Calcium D-Glucarate is a compound formed when calcium binds to D-glucaric acid — a substance the body produces in small amounts and that's naturally found in broccoli, kale, cabbage, apples, oranges, and grapefruit. This Designs for Health formula delivers 1,200mg per serving, providing a concentrated, slow-release source of its most active metabolite. When you ingest calcium D-glucarate, your body converts it into D-glucaro-1,4-lactone. This metabolite works by inhibiting beta-glucuronidase, an enzyme that can interfere with the liver's glucuronidation pathway — one of the body's primary routes for packaging up toxins and excess hormones for elimination. When beta-glucuronidase goes unchecked, toxins and estrogen metabolites can get reabsorbed into circulation rather than excreted. Calcium D-glucarate helps keep that process moving in the right direction. This formula is non-GMO, gluten-free, dairy-free, and vegetarian — made with minimal excipients and no unnecessary fillers. Designs for Health is the #1 practitioner-recommended supplement brand among functional medicine professionals in the US. Ideal for those supporting liver health, managing estrogen load, or looking to reinforce their body's natural detox capacity.