O-Linked N-Acetylglucosamine Recombinant Rabbit mAb (S-R256)
type: Product
description: Product Details Product Specification Host Rabbit Antigen O-Linked N-Acetylglucosamine Synonyms O-GlcNAc Clone Number S-R256 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC-P, ICC Reactivity Species Independent Purification Protein A Concentration 0.5 mg/ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied Dilution application dilution species WB 1:500 IHC 1:500 ICC 1:500 Background O-GlcNAc (short for O-linked GlcNAc or O-linked β-N-acetylglucosamine) is a reversible enzymatic post-translational modification that is found on serine and threonine residues of nucleocytoplasmic proteins. The modification is characterized by a β-glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc). It has been suggested that apoptosis is regulated by O-GlcNAc. In various cancers, elevated O-GlcNAc levels have been reported to suppress apoptosis. Caspase-3, caspase-8, and caspase-9 have been reported to be modified by O-GlcNAc. Caspase-8 is modified near its cleavage/activation sites; O-GlcNAc modification may block caspase-8 cleavage and activation by steric hindrance. Pharmacological lowering of O-GlcNAc with 5S-GlcNAc accelerated caspase activation while pharmacological raising of O-GlcNAc with thiamet-G inhibited caspase activation. Picture Western Blot WB result of O-Linked N-Acetylglucosamine Rabbit mAb Primary antibody: O-Linked N-Acetylglucosamine Rabbit mAb at 1/500 dilution Lane 1: A431 whole cell lysate 20 µg Lane 2: 293T whole cell lysate 20 µg Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution Predicted MW: Multiple kDa Observed MW: Multiple kDa (This blot was developed with high sensitivity substrate) WB result of O-Linked N-Acetylglucosamine Rabbit mAb Primary antibody: O-Linked N-Acetylglucosamine Rabbit mAb at 1/500 d…
brand: AntBio
sku: S0B0373
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