BPC+KPV+PEA 500 is an advanced oral peptide and lipid mediator formula combining Body Protection (a 15-amino acid sequence available as the highly stable and orally bioavailable arginate salt), KPV (Lysine-Proline-Valine tripeptide), and Palmitoylethanolamide (PEA) at 500 mg, with salcaprozate sodium (SNAC) as a precision oral delivery system, designed to support healthy inflammatory response and tissue homeostasis across the gut, connective tissue, and neuro-immune axis through three complementary mechanisms that address tissue repair signaling, epithelial barrier function, and endocannabinoid-mediated neuro-immune balance simultaneously. Body Protection, a 15-amino acid sequence that has been studied across a wide range of tissue health and recovery applications, is the lead active compound in this formula. The arginate salt form used by Healthgevity is specifically selected for oral supplementation because of its exceptional chemical stability and oral bioavailability, the two properties that most other peptide forms cannot reliably provide in the harsh gastrointestinal environment. Peptides are inherently vulnerable to degradation by gastric acid and proteolytic enzymes in the stomach and small intestine, and most peptide supplement forms lose significant activity before reaching systemic circulation. The arginate salt of Body Protection addresses this through inherent molecular stability, and this stability is further supported by the inclusion of SNAC in the formula. KPV is the tripeptide sequence Lysine-Proline-Valine, a naturally occurring peptide fragment studied for its role in supporting healthy inflammatory response and epithelial barrier function in mucosal tissue, particularly in the gut lining. KPV has been documented to reach the intestinal epithelium and support barrier integrity and tissue homeostasis in gastrointestinal and connective tissue environments, making it a natural complement to Body Protection's tissue signaling activity in a formula positioned for gut comfort, gut barrier support, and connective tissue health. PEA (Palmitoylethanolamide) at 500 mg is a naturally occurring fatty acid amide lipid mediator that the body produces on demand in response to tissue stress, injury, and inflammation. It operates through PPAR-alpha receptor activation, which supports resolution of inflammatory signaling and promotes tissue homeostasis, and through the entourage effect on the endocannabinoid system by inhibiting FAAH (the same enzyme that degrades anandamide), extending endogenous cannabinoid tone. PEA also supports mast cell stabilization and glial cell modulation in the neuro-immune system. At 500 mg, this is a meaningful therapeutic dose aligned with the clinical research literature for PEA. SNAC (salcaprozate sodium) is a proven oral delivery enhancer used in pharmaceutical oral peptide formulations, most notably in the oral semaglutide formulation (Rybelsus) for type 2 diabetes. SNAC works by transiently and locally raising the pH in the stomach microenvironment surrounding the active compounds, reducing protease activity and supporting absorption through the gastric mucosa before the compounds reach the more hostile small intestinal enzyme environment. Its inclusion in BPC+KPV+PEA 500 represents a meaningful clinical upgrade over peptide supplements that rely solely on capsule encapsulation for GI protection. Available in 30-serving ($149.99) and 60-serving ($224.99) sizes. Refer to the product label for exact milligram supplement facts per ingredient. Key Benefits: Body Protection arginate salt provides a highly stable, orally bioavailable 15-amino acid sequence for tissue signaling support Supports healthy inflammatory response and tissue homeostasis in the gut and connective tissue KPV (Lysine-Proline-Valine) supports epithelial barrier function and mucosal tissue integrity PEA 500 mg supports neuro-immune homeostasis, healthy inflammatory tone, and GI comfort via PPAR-alpha and endocannabinoid signaling PEA supports mast cell stabilization and glial cell modulation for neuro-immune balance SNAC delivery system protects active peptide compounds through the GI environment for consistent oral uptake Optimal SNAC-to-active ingredient ratio for maximum peptide absorption without compromising stability or efficacy Supports gut barrier function, gut lining integrity, and digestive comfort Supports connective tissue health and recovery Supports healthy nervous system and immune system balance through PEA's neuro-immune activity Three complementary mechanisms: tissue repair peptide signaling, epithelial barrier support, and lipid mediator neuro-immune homeostasis What's Inside — Key Ingredients (refer to product label for exact mg per serving): Body Protection (15-Amino Acid Arginate Salt) Body Protection is a 15-amino acid sequence that has been studied across a broad range of tissue health, recovery, and homeostasis applications. Healthgevity's formulation uses the arginate salt form, selected specifically for its exceptional oral stability and bioavailability compared to other forms of this peptide sequence. The arginate salt resists degradation in the gastric acid and proteolytic enzyme environment of the stomach, maintaining structural integrity that preserves activity through to systemic absorption. Body Protection has been studied in preclinical and early clinical research for its effects on tissue healing, gut mucosal integrity, inflammatory balance, and systemic recovery, with a breadth of studied applications that reflects its role as a pleiotropic signaling peptide active across multiple tissue types and biological systems. KPV (Lysine-Proline-Valine Tripeptide) KPV is a naturally occurring anti-inflammatory tripeptide that is a C-terminal fragment of alpha-melanocyte-stimulating hormone. It has been studied for its ability to support healthy inflammatory signaling in mucosal and epithelial tissue, to support intestinal epithelial barrier function and gut lining integrity, and to promote tissue homeostasis in gastrointestinal environments. Research indicates KPV can reach intestinal epithelial cells and exert direct anti-inflammatory effects in the mucosal lining. Its inclusion alongside Body Protection in this formula provides a complementary short-peptide approach to gut barrier and inflammatory balance that addresses the epithelial dimension of intestinal health alongside Body Protection's broader tissue signaling activity. Palmitoylethanolamide (PEA) — 500 mg PEA is a naturally occurring endogenous fatty acid amide produced by cells throughout the body on demand in response to tissue injury, inflammatory challenge, and neurological stress. It acts as an autacoid local injury antagonist, modulating the inflammatory and pain response at the site of tissue stress. Its primary molecular targets include PPAR-alpha (Peroxisome proliferator-activated receptor alpha), where activation promotes resolution of inflammatory signaling and supports metabolic and immune homeostasis in affected tissue, and the endocannabinoid system through FAAH inhibition, extending the activity of anandamide and other endocannabinoids for broader neuro-immune comfort signaling. PEA also stabilizes mast cells, reducing histamine and cytokine release in response to tissue stress, and modulates microglial and astrocyte activity in the central nervous system for neurological comfort and neuro-immune balance. At 500 mg, this delivers a clinically studied dose consistent with the human research literature on PEA. Salcaprozate Sodium (SNAC) SNAC is a pharmaceutical-grade oral bioavailability enhancer with an established track record in drug delivery science, where it is used to enable the oral absorption of compounds that would otherwise be degraded in the gastrointestinal tract. SNAC works by forming a complex with active compounds and transiently raising the local gastric pH microenvironment surrounding the complex, reducing protease activity and supporting direct gastric mucosal absorption before the compounds encounter the small intestinal enzyme environment. Healthgevity's optimal SNAC-to-active ratio is specifically calibrated to maximize peptide protection and absorption without compromising the stability or efficacy of the Body Protection arginate salt or KPV. Refer to the product label for complete other ingredients and allergen information. Storage Store in a cool, dry place. Keep out of reach of children. Directions Take as directed on the product label or as recommended by your healthcare professional. Best taken on an empty stomach for optimal SNAC-mediated gastric absorption. Consult your healthcare professional before use if pregnant, nursing, taking medications, or have a medical condition. Healthgevity BPC+KPV+PEA 500 is a practitioner-trusted oral peptide and lipid mediator formula available at SOLUDE Wellness & Beauty. It contains Body Protection (15-amino acid arginate salt for oral stability and bioavailability), KPV (Lysine-Proline-Valine tripeptide), Palmitoylethanolamide (PEA) 500 mg, and Salcaprozate Sodium (SNAC) oral delivery system per serving. It is designed to support healthy inflammatory response and tissue homeostasis in the gut and connective tissue, epithelial barrier function and gut lining integrity via KPV, neuro-immune homeostasis and GI comfort via PEA PPAR-alpha and endocannabinoid signaling, mast cell stabilization and glial cell modulation via PEA, and consistent oral peptide uptake via SNAC GI protection. Oral arginate salt Body Protection for exceptional stability. Optimal SNAC-to-active ratio for maximum absorption. Available in 30-serving and 60-serving sizes. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.