Recombinant Mouse Flt-3 Ligand/FLT3L Protein, Active

Product Overview Product Name Recombinant Mouse Flt-3 Ligand/FLT3L Protein Target Symbol FLT3LG Alternative Names fms-like Tyrosine Kinase 3 Ligand, FLT3L, Flt3 Ligand, FLG3L, SL Cytokine Accession Number P49771 Expression System E. coli. Sequence Gly27-Arg188 Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining Activity Determined by in-house activity assay Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4 Endotoxin Level Available Upon Request Shipping Shipped at ambient temperature. Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. Reconstitution Reconstitute at 100 ug/mL in sterile PBS. Target Function Flt-3L (Fms-related tyrosine kinase 3 ligand) is a protein that plays a role in regulating the survival, expansion and differentiation of hematopoietic stem cells (HSCs), including progenitor cells in both the lymphoid and myeloid lineages. Flt-3L also promotes expansion and differentiation of dendritic cells, NK cells and B cells. Flt-3L is expressed as both membrane-bound and soluble isoforms, both of which initiate signaling through binding to the receptor, Flt3 (CD135/Flk2). Tissue Specificity Flt-3L expression has been reported in bone marrow stromal cells, brain, thymus, placenta, spleen, testes, and lymph nodes. Cellular Localization Membrane-bound and cleaved soluble protein forms Involvement In Disease Dysregulation of Flt-3L is associated with aplastic anemia and acute myeloid leukemia.