Recombinant Human BMP-2 Protein, Active

Product Overview Product Name Recombinant Human BMP-2 Protein Target Symbol BMP2 Alternative Names Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 2A, BMP2, BMP2A, BDA2, SSFSC, SSFSC1 Accession Number P12643 Expression System E. coli. Molecular Weight 13 kDa (monomer, predicted) Sequence Gln283-Arg396, with an N-terminal Met Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining Activity Determined by in-house activity assay Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4 Endotoxin Level Available Upon Request Shipping Shipped at ambient temperature. Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. Reconstitution Reconstitute at 100 ug/mL in sterile PBS. Target Function Bone Morphogenetic Protein 2 (BMP-2) mediates several functions related to cartilage and bone formation. During embryonic development, BMP-2 contributes to dorsal-ventral patterning of the developing neural tube, and influences differentiation of endoderm, mesenchymal cells, and chondrocytes. In response to tissue damage, BMP-2 promotes chondrogenesis, migration of keratinocytes, and angiogenesis. BMP-2 signaling occurs via binding to BMPR1A (CD292) and BMPR2, at which point BMPR2 transphosphorylates BMPR1A to induce the Smad signaling pathway. Tissue Specificity BMP-2 expression has been identified in ectoderm, mesoderm, endoderm, developing skeletal tissues such as cartilage and bone, the developing central nervous system, including the neural tube and the brain, heart, kidney, lung, and skin. Cellular Localization Secreted protein Involvement In Disease Dysregulation of BMP-2 is associated with osteoporosis, atherosclerosis, congenital heart defects, Alzheimer’s disease, Parkinson’s disease, insulin resistance, type 2 diabetes, osteoarthritis, and various cancers due to BMP-2 enhanced invasion and metastasis of cancer cells.