Leuco-Exo(SH) | Microbial Exosome / Extracellular Vesicles

GFC Life Sciences · Microbial Exosome Technology Leuco-Exo(SH) Microbial Extracellular Vesicle for Hair & Skin Bring next-generation exosome science to your cosmetic formulations. Leuco-Exo(SH) delivers Leuconostoc extracellular vesicles isolated via GFC's proprietary Hybrid-Exotech method. With ~118.2 nm particles, 7 hair-growth-factor response data, and a 12-week human hair-density study, this is a specialised active for professional scalp and skincare development. What is Leuco-Exo(SH)? Leuco-Exo(SH) is GFC Life Sciences' microbial extracellular vesicle ingredient, isolated from its proprietary Leuconostoc GFC1203H strain using the Hybrid-Exotech method. It is supplied as a colourless, clear liquid in a water-based carrier. INCI: Water, Butylene Glycol, 1,2-Hexanediol, Leuconostoc Extracellular Vesicles This is a cosmetic raw material for professional formulators. It is not a finished consumer product. The Science Behind It What Are Exosomes? Extracellular vesicles (exosomes) are nanoscale membrane-bound particles (approximately 50–200 nm) released by cells. They carry proteins, nucleic acids, DNA, mRNA, and lipids, functioning as messengers that transmit genetic information between cells. Their natural roles include tissue growth, regeneration, and immune regulation. The Leuco-Exo Difference Leuco-Exo is specifically microbe-derived. GFC's research began with scalp sampling across age groups (n=80), leading to the identification of a lactic acid bacterial strain associated with people in their teens and twenties: Leuconostoc GFC1203H. This strain was identified through 16S rDNA sequencing and deposited under patent KCTC14077BP. The vesicles feature a phospholipid-bilayer structure (the same architecture as human cell membranes) and have been characterised by Nanoparticle Tracking Analysis (NTA) at approximately 118.2 nm. At this scale, they are 184–462 times smaller than skin pores, supporting efficient delivery to target cells. Key Benefits & Research Data Nanoscale Characterisation ~118.2 nm particle size confirmed by NTA Hair Growth Factors (In Vitro) Increased all 7 assessed hair-growth factors with Leuco-Exo treatment Human Hair Density Study 14.54% improvement at 12 weeks (Korea Dermatology Research Institute) Skin Regeneration (In Vitro) ~50% greater wound-healing response vs. control Cell Survival (In Vitro) Inhibited cell death and increased growth rate in apoptosis assay Antioxidant Activity Greater free-radical scavenging than the type strain Scalp Health Support Inhibits bacteria associated with dandruff and scalp inflammation KGF Expression Keratinocyte Growth Factor (KGF) mRNA expression in hair-growth research Specifications Product Leuco-Exo(SH) Manufacturer GFC Life Sciences Co., Ltd. INCI Water, Butylene Glycol, 1,2-Hexanediol, Leuconostoc Extracellular Vesicles Source Strain Leuconostoc GFC1203H Strain Deposit KCTC14077BP Isolation Method Hybrid-Exotech Particle Size ~118.2 nm (NTA confirmed) Appearance Colourless, clear liquid Odour Slightly characteristic pH 5.00 – 9.00 Specific Gravity 0.990 – 1.010 Refractive Index 1.335 – 1.345 Recommended Usage 1.0 – 4.0% Storage Store in a cool, dry place in a well-closed container, protected from light Shelf Life 2 years from date of production Recommended Applications Leuco-Exo(SH) is ideal for formulators developing advanced scalp and skincare products: Scalp Serums Hair Tonics Hair Growth Formulations Facial Serums Ampoules Skin Repair Creams Anti-Aging Skincare Skin-Conditioning Products Usage & Formulation Notes Recommended concentration: 1.0 – 4.0% of the supplied Leuco-Exo(SH) ingredient. Always refer to current GFC Life Sciences technical documentation when developing your finished cosmetic formulation. This is a raw material; final formulation stability, compatibility, and efficacy must be evaluated by a qualified cosmetic chemist for your specific product. Frequently Asked Questions What is the INCI name? Water, Butylene Glycol, 1,2-Hexanediol, Leuconostoc Extracellular Vesicles. Is this human stem-cell exosome? No. Leuco-Exo contains microbial extracellular vesicles derived from Leuconostoc GFC1203H, isolated using GFC's proprietary Hybrid-Exotech method. What makes this ingredient distinctive? Its proprietary scalp-derived microbial strain (GFC1203H), ~118.2 nm NTA-characterised particles, and research spanning hair-growth-factor responses, human hair density, and skin-cell regeneration assays. What did the human hair study find? The Korea Dermatology Research Institute study reported test-group hair-density improvements of 9.41% at week 4, 12.02% at week 8, and 14.54% at week 12. What usage range is recommended? GFC recommends 1.0 – 4.0% of the supplied ingredient in finished cosmetic formulations. Is this the same as Salmon PDRN? No. Leuco-Exo is a microbial extracellular-vesicle ingredient. Salmon PDRN is a different ingredient category (DNA fragments derived from salmon). They are not the same and are not interchangeable. Is a COA available? Yes. COA is available upon request. Disclaimer For professional external cosmetic use only. Not for injection or ingestion. Research summaries are based on GFC Life Sciences' supplied material and relate to the stated test conditions; they do not guarantee identical performance in every finished cosmetic. No guaranteed hair-regrowth, hair-loss-treatment, or wound-healing claims are made. Cosmeti Hub supplies ingredients, not complete formulations. Consult a qualified cosmetic chemist for formulation guidance and finished-product assessment.