CultureGro™ Human Oncostatin M (209 a.a.) Animal Free Recombinant Protein

Oncostatin M (OSM) is a multifunctional growth and differentiation factor involved in regulating neurogenesis, osteogenesis, and hematopoiesis. It is produced by activated T cells, monocytes, and Kaposi’s sarcoma cells, exerting both stimulatory and inhibitory effects on cell proliferation. OSM stimulates the growth of fibroblasts, smooth muscle cells, and Kaposi’s sarcoma cells, while it inhibits the proliferation of certain normal and tumor cell lines. Additionally, OSM promotes the release of cytokines like IL-6, GM-CSF, and G-CSF from endothelial cells and enhances low-density lipoprotein receptor expression in hepatoma cells. Structurally and functionally, OSM shares characteristics with LIF, IL-6, and CNTF. It is biologically active on murine cells. The human OSM gene encodes a 252 amino acid polypeptide with a 25 amino acid signal sequence for secretion, forming a 227 amino acid precursor protein. Proteolytic cleavage of this precursor removes an 18 amino acid C-terminal peptide to yield the mature OSM form. Recombinant Human Oncostatin M is a 23.6 kDa protein consisting of 209 amino acid residues.