VCAM-1/CD106 Recombinant Rabbit mAb (SDT-2462-2)

Product Specification Host Rabbit Antigen CD106 Synonyms Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; INCAM-100; CD106; VCAM1 Immunogen Recombinant Protein Accession P19320-1 Clone Number SDT-2462-2 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross-reactivity against ICAM-1, E-selectin Purification Protein A Concentration 2 mg/ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7.4, 0.03% Proclin 300 Stability & Storage 12 months from date of receipt, 2 to 8 °C as supplied BackgroundCD106, also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein encoded by the VCAM1 gene in humans and belongs to the immunoglobulin superfamily. It is a cytokine-inducible cell surface protein that mediates the adhesion of leukocytes to vascular endothelium, playing a crucial role in immune responses and inflammation. CD106 is primarily expressed on endothelial cells, but its expression can also be found in other cell types such as smooth muscle cells and mesenchymal stem cells. The upregulation of CD106 in endothelial cells is induced by cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), and it is involved in various pathological conditions, including atherosclerosis and rheumatoid arthritis. In addition, CD106 is essential for embryonic development, particularly in the formation of the umbilical cord and placenta.