Capcell Pak ADME-HR HPLC Columns

CAPCELL PAK ADME-HR HPLC Columns Enhanced Retention of Polar Compounds in Reversed-Phase HPLC CAPCELL PAK ADME-HR HPLC columns utilize a unique adamantyl stationary phase designed to provide enhanced retention and selectivity for polar compounds under reversed-phase conditions. Unlike conventional C18 columns, ADME-HR delivers: Increased retention of highly polar analytes Alternative selectivity for challenging separations Stable performance under highly aqueous mobile phases 👉 Ideal for applications where traditional C18 columns fail to retain polar compounds effectively. 🔬 Why ADME-HR is Different from C18 The ADME-HR stationary phase uses a cage-structured adamantyl functional group, providing a unique balance of: Hydrophobic interaction Surface polarity This results in: Retention behavior not achievable with standard C18 columns Improved separation of polar metabolites and compounds Greater flexibility in reversed-phase method development ⚖️ ADME-HR vs C18 Columns C18: Strong hydrophobic retention, weak for polar compounds ADME-HR: Balanced retention with enhanced polarity interaction 👉 ADME-HR is the solution when: Polar analytes elute too early Retention is insufficient Selectivity needs improvement 🧪 Applications Pharmaceutical Analysis Polar drug compounds Metabolites Nucleic acid-related compounds Biochemical Analysis Nucleosides and nucleotides Amines and polar biomolecules Food and Environmental Polar contaminants Additives and small molecules 🔬 Key Features Adamantyl stationary phase (ADME chemistry) Strong retention of polar analytes Stable under 100% aqueous mobile phase Unique selectivity vs conventional C18 Excellent peak shape and reproducibility ⚠️ When to Choose ADME-HR Use this column when: Polar compounds are poorly retained on C18 Separation selectivity needs improvement Aqueous mobile phases are required You want to maintain reversed-phase conditions 🔧 Available Configurations Particle sizes: 2 µm, 3 µm, 5 µm Column IDs: 2.1 mm, 4.6 mm Lengths: 50–250 mm 📞 Request Information 👉 Request a quote 👉 Request application support 👉 Speak with an HPLC specialist Contact Info: sales@jmscience.com; Tel: 716-774-8706