Resolve+ is a six-pathway inflammatory balance formula combining seven clinically studied, precision-formulated ingredients, including the world's first endocannabinoid-modulating ingredient in a practitioner anti-inflammatory supplement, designed to support healthy inflammatory response balance, joint comfort and flexibility, muscle recovery, cellular antioxidant defense, respiratory and histamine balance, and systemic vitality through a multi-mechanism approach that addresses every major inflammatory signaling pathway simultaneously rather than targeting a single enzyme or transcription factor the way most curcumin and Boswellia supplements do. Most inflammatory support supplements are single-pathway formulas. They deliver curcumin for NF-kB inhibition, or Boswellia for 5-LOX inhibition, or quercetin for antioxidant and mast cell support. The fundamental limitation of this approach is that chronic, age-related, or lifestyle-driven inflammatory signaling does not operate through one pathway. It operates through the endocannabinoid system, NF-kB transcription, COX and LOX enzyme cascades, oxidative stress signaling, gut-immune inflammatory tone, and cellular antioxidant defense networks simultaneously. Addressing one while leaving five untouched produces incomplete clinical results. Resolve+ was designed around this reality. Its six-pathway system covers: endocannabinoid modulation through CB2 receptor agonism and FAAH inhibition (Acmella oleracea spilanthol), NF-kB pathway and cytokine balance through a dual curcuminoid system (Theracurmin Super 85X plus CurcuPrime tetrahydrocurcumin), 5-lipoxygenase inhibition and leukocyte migration support (Casperome Boswellia Phytosome with AKBA), broad polyphenol antioxidant and immune defense at 20x bioavailability (Quercetin Phytosome Quercefit), respiratory comfort, histamine balance, and multi-pathway flavone support (Perilla frutescens seed extract with rosmarinic acid, luteolin, and apigenin), and enhanced absorption across all ingredients (AstraGin 50 mg). Every active compound in this formula is delivered through a bioavailability-enhanced form: amorphous conversion technology, phytosome phospholipid complexation, or standardized extract, making Resolve+ not only the most mechanistically comprehensive inflammatory support formula in your store but also the most bioavailability-engineered. $79.99. Refer to the product label for exact milligram supplement facts per ingredient. Key Benefits: Supports healthy inflammatory response balance through six distinct and complementary mechanisms Acmella oleracea spilanthol provides CB2 receptor agonism and FAAH inhibition for endocannabinoid-mediated inflammatory and comfort support Theracurmin Super 85X delivers amorphous curcumin at 85x greater bioavailability than standard curcumin for NF-kB and cytokine balance CurcuPrime tetrahydrocurcumin delivers curcumin's active metabolite directly for sustained antioxidant and Nrf2 activity Casperome Boswellia Phytosome with AKBA inhibits 5-lipoxygenase for LOX pathway inflammatory balance and joint support Quercetin Phytosome (Quercefit) provides 20x bioavailability quercetin for broad antioxidant, mast cell, and immune modulation Perilla frutescens provides rosmarinic acid, luteolin, and apigenin for respiratory comfort, histamine balance, and NAD+ homeostasis support AstraGin 50 mg upregulates intestinal nutrient transporters for enhanced absorption across all active compounds Supports joint comfort, flexibility, and healthy mobility Supports muscle recovery and reduced exercise-associated discomfort Supports gut-immune inflammatory balance via AstraGin gut barrier activity Supports vascular and tissue health through broad polyphenol and antioxidant activity Supports respiratory comfort and healthy histamine and seasonal immune response What's Inside — Full Ingredient Breakdown (refer to product label for exact mg per serving): Acmella oleracea (Jambu Extract, standardized for Spilanthol) — Sustainably Sourced from Sardinia, Italy The most distinctive and clinically novel ingredient in Resolve+. Acmella oleracea, known as jambu or the toothache plant, provides spilanthol, a bioactive alkylamide that engages the endocannabinoid system through two complementary mechanisms not addressed by any other ingredient in the practitioner inflammatory support category. First, spilanthol acts as a direct CB2 receptor agonist, activating the peripheral cannabinoid receptors expressed on immune cells, joints, and connective tissue where CB2 activation supports healthy inflammatory tone and comfort signaling without any psychoactive effects (CB2 activation is distinct from CB1 activation, which is associated with CNS effects). Second, spilanthol inhibits FAAH (fatty acid amide hydrolase), the enzyme that breaks down anandamide and other endocannabinoids, supporting higher endogenous cannabinoid tone and extending their comfort and anti-inflammatory signaling activity. Spilanthol also crosses the blood-brain barrier, providing central as well as peripheral effects, and has been documented to modulate the NF-kB pathway, inhibit iNOS, COX-2, IL-1B, IL-6, and TNF-alpha in preclinical models, and exert local sodium channel modulation for tissue comfort. A 2025 systematic review of the Acmella genus confirmed consistent anti-inflammatory, analgesic, and anti-arthritic properties across clinical and preclinical evidence. A 2024 observational study confirmed the specific combination of Acmella oleracea with Boswellia, which is the pairing in this formula, for musculoskeletal comfort and mobility. Theracurmin Super 85X (Amorphous Curcumin, 36% Curcumin) The highest-bioavailability curcumin formulation in the Theracurmin series, delivering amorphous nano-particle curcumin that disperses readily in the aqueous gut environment unlike crystalline curcumin which resists dissolution. Clinical pharmacokinetic research has documented 35.9 to 42.6-fold higher AUC versus unformulated curcumin powder, with Theracurmin Super further demonstrating 1.54-fold higher Cmax at half the dose versus the earlier Theracurmin generation. A 2024 randomized double-blind placebo-controlled trial confirmed significant effects on oxidative stress index in healthy adults following exercise-induced oxidative stress, and a 12-month double-blind placebo-controlled trial demonstrated chondroprotective activity and improved anti-inflammatory markers for joint health support. At effective absorbed doses, Theracurmin Super targets NF-kB pathway inhibition, COX-2 and iNOS downregulation, Nrf2 pathway activation for endogenous antioxidant upregulation, and direct free radical scavenging. CurcuPrime (Tetrahydrocurcumin) Tetrahydrocurcumin (THC) is the primary active metabolite that curcumin is converted to in the body, delivered directly in CurcuPrime for consistent and predictable bioavailability independent of individual metabolic conversion capacity. Tetrahydrocurcumin provides more potent direct antioxidant activity than parent curcumin through greater DPPH radical scavenging capacity, is metabolically more stable with longer circulating half-life than parent curcumin, activates Nrf2 for Phase II detoxification enzyme induction, and provides complementary NF-kB and cytokine pathway modulation. Together, Theracurmin Super 85X and CurcuPrime provide a dual curcuminoid system: Theracurmin for rapid, highly bioavailable parent curcumin activity and CurcuPrime for sustained active metabolite coverage, addressing both the acute and sustained dimensions of curcuminoid anti-inflammatory activity in one formula. Casperome (Boswellia serrata Resin Extract, standardized to AKBA) Indena's clinically studied Phytosome formulation of Boswellia serrata resin standardized to boswellic acids including AKBA (acetyl-11-keto-B-boswellic acid), the most pharmacologically active boswellic acid for 5-lipoxygenase (5-LOX) inhibition. Boswellia's 5-LOX mechanism is directly complementary and non-redundant to curcumin's primarily COX-pathway activity, together addressing both major arachidonic acid inflammatory cascades simultaneously. AKBA also supports healthy leukocyte elastase activity and modulates LFA-1 binding to limit leukocyte migration to sites of tissue stress. Multiple randomized controlled human trials confirm Casperome for joint comfort, mobility, and physical function. The Phytosome phospholipid complexation dramatically improves boswellic acid oral absorption over standard Boswellia extracts. Quercetin Phytosome (Quercefit) Indena's patented quercetin phytosome delivering quercetin complexed with lecithin phospholipids for up to 20-fold higher bioavailability versus standard quercetin aglycone, confirmed by a 2024 systematic review and meta-analysis of 31 human intervention studies. In Resolve+, Quercefit provides broad-spectrum antioxidant and immune-modulating coverage across pathways not specifically addressed by curcumin's NF-kB focus or Boswellia's 5-LOX focus, including inhibition of pro-inflammatory kinases and AP-1 transcription, mast cell stabilization and healthy histamine response, antioxidant activity across both lipophilic and hydrophilic cellular compartments, regulatory T-cell activity support, vascular integrity and endothelial health, and healthy uric acid metabolism. Perilla frutescens Seed Extract A natural three-bioactive complex providing rosmarinic acid (a caffeic acid ester supporting healthy histamine response, DAO enzyme function, complement activation balance, and mast cell activity), luteolin (a flavone with NF-kB inhibitory and antioxidant activity complementing curcumin through flavone-mediated pathways), and apigenin (supporting NAD+ homeostasis through CD38 modulation alongside independent antioxidant and anti-inflammatory activity). Perilla frutescens adds a respiratory comfort and histamine balance dimension that makes Resolve+ clinically relevant for clients where systemic inflammatory tone, respiratory challenges, and seasonal immune concerns are concurrent clinical priorities alongside the joint and muscle recovery positioning. AstraGin (Astragalus membranaceus + Panax notoginseng Root Extracts) — 50 mg A patented combination that upregulates intestinal nutrient transporter proteins, supporting the consistent absorption and bioavailability of Resolve+'s active polyphenol compounds across individuals with varying GI function. AstraGin also supports gut barrier integrity and healthy intestinal inflammatory tone, contributing directly to the gut-immune inflammatory balance dimension of the formula's clinical positioning. Storage Store in a cool, dry place. Keep out of reach of children. Directions Take as directed on the product label or as recommended by your healthcare professional. Consistent daily use is recommended for progressive multi-pathway inflammatory balance support. Consult your healthcare professional before use if pregnant, nursing, taking medications, or have a medical condition. Healthgevity Resolve+ is a practitioner-trusted six-pathway inflammatory balance supplement available at SOLUDE Wellness & Beauty. It contains Acmella oleracea Jambu Extract standardized for Spilanthol (CB2 agonist, FAAH inhibitor, sourced from Sardinia Italy), Theracurmin Super 85X (amorphous curcumin 36% curcumin, 85x bioavailability), CurcuPrime (Tetrahydrocurcumin, active curcumin metabolite), Casperome (Boswellia serrata Phytosome standardized to AKBA, 5-LOX inhibitor), Quercetin Phytosome (Quercefit, 20x bioavailability), Perilla frutescens Seed Extract (rosmarinic acid, luteolin, apigenin), and AstraGin 50 mg (Astragalus membranaceus and Panax notoginseng, absorption enhancement). It is designed to support healthy inflammatory response balance through endocannabinoid CB2 and FAAH modulation, NF-kB pathway and cytokine balance via dual curcuminoid system, 5-LOX inhibition via AKBA Boswellia, broad antioxidant and immune defense via 20x quercetin, respiratory comfort and histamine balance via Perilla frutescens, and gut barrier integrity and bioavailability enhancement via AstraGin. The only practitioner inflammatory formula with Acmella oleracea endocannabinoid support. Six pathways. Seven ingredients. One formula. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.