⚕️ RX | Cytopoint: Lokivetmab (Allergy Injection)

Cytopoint (lokivetmab) is a prescription injectable monoclonal antibody from Zoetis that controls itch associated with allergic dermatitis and atopic dermatitis in dogs, with a single injection typically providing 4 to 8 weeks of relief. Rather than a daily drug, lokivetmab is an antibody therapy that targets and neutralizes interleukin-31 (IL-31), a key cytokine that carries the itch signal, and most dogs itch less within 24 hours of an injection. ⚠️ Prescription Injectable Medication — Cold-Chain Shipping Required 🆕 First-Time Order? A Consultation is Required Before we can dispense this medication for the first time, we require: A valid prescription from your licensed veterinarian A Smarty Vets prescription consultation — we'll cover injection technique, safe handling, side effects, and cold-chain shipping details 👉 Book your free consultation here to get started. 🔁 Already a Patient? Order Refills Directly If your pet has been on this medication for at least 60 days without side effects, you can order refills on your own — no additional consultation needed. Simply upload your valid prescription at checkout We'll verify and ship your refill 🧊 Cold-Chain Shipping Information These medications must remain temperature-controlled. They will be shipped in an insulated cooler with ice packs via FedEx Priority Overnight to maintain product integrity. Shipping cost: $60 per order, regardless of the number of vials included. Key facts Active ingredient: lokivetmab, a caninized anti-IL-31 monoclonal antibody Species: dogs only Available sizes: 10 mg, 20 mg, 30 mg, and 40 mg vials, sold individually or in boxes of 5 Form: injectable solution (refrigerated, cold-chain shipped) Duration: one injection typically controls itch for 4-8 weeks Typical use: itch from allergic dermatitis and atopic dermatitis, seasonal or year-round Manufacturer: Zoetis How to use Cytopoint is given as a subcutaneous (under-the-skin) injection. The vial strength and dose are selected by the prescribing veterinarian based on your dog's body weight, and injections are repeated every 4 to 8 weeks as needed to maintain itch control. Store vials refrigerated at 36-46°F (2-8°C); do not freeze. Safety information Because lokivetmab is an antibody rather than a conventional drug, it is broken down and recycled by the body like natural proteins. It is generally well tolerated; uncommon reactions can include vomiting, lethargy, or hypersensitivity. Cytopoint is for dogs only and should be used under the direction of your veterinarian. Frequently asked questions How does Cytopoint work? Lokivetmab binds and neutralizes interleukin-31 (IL-31), the cytokine that transmits the itch signal to the brain in allergic dogs, reducing scratching at its source. How fast does Cytopoint start working? Most dogs show reduced itching within 24 hours of the injection. How long does one Cytopoint injection last? A single injection typically controls itch for 4 to 8 weeks; your veterinarian will recommend a repeat schedule based on your dog's response. What is the difference between Cytopoint and Apoquel? Cytopoint is an injectable antibody given every 4-8 weeks, while Apoquel (oclacitinib) is a daily oral JAK-inhibitor tablet. Learn more in our guide, What you need to know about Apoquel. Is a prescription required for Cytopoint? Yes. Cytopoint requires a valid prescription from a veterinarian who has examined your dog, and first-time injectable orders at Smarty Vets include a free prescription consultation. Can cats receive Cytopoint? No. Cytopoint is designed specifically for dogs and is not approved for cats. Prefer a daily oral option? See Apoquel (oclacitinib) tablets for dogs.