FAT3 (human) antibody

Anti-FAT3 (human) antibody is recommended for immunofluorescence labeling, IHC, or western blot of materials from human tissues. Protocadherin FAT3 is a protein that is encoded by the FAT3 gene in human. This gene is an orthologue of the Drosophila fat gene. FAT is involved in establishing the planar polarity in Drosophila cells. Like classic cadherins, protocadherin proteins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. Compared to classic cadherins, the ectodomains in protocadherins are much larger. FAT3 is highly expressed by the photoreceptor cells in the retina, appearing to constitute the connecting cilium, the equivalent of primary cilium in the epithelial cells. Anti-FAT3 (human) antibody is raised against a homologous epitope to anti-FAT3 (rodent) antibody (Cat No: 50503).