cFluor® R780 Anti-Human HLA-DR (L243)
type: Product
description: The mouse monoclonal antibody clone L243 binds to the human HLA-DR antigen, a 36 kDa alpha heavy chain, and a 27 kDa beta light chain heterodimeric cell surface glycoprotein in the transmembrane major histocompatibility complex 2 (MHC II) family. HLA-DR, also known as human leukocyte antigen DR isotype, is present on the surface of antigen-presenting cells including, B cells, dendritic cells, macrophages, monocytes, and activated T cells. MHC class II regulates the immune system by playing a critical role in binding and presenting antigen-derived peptides to peptide-MHC II-specific CD4 T cells. The L243 clone identifies HLA-DR molecules, whether peptide-loaded or unoccupied. It does not exhibit cross-reactivity with HLA-DP and HLA-DQ. Clone L243 interacts with a conformational epitope on HLA-DRα, contingent upon the proper folding of the αβ heterodimer. PRODUCT DETAILSClone: L243Specificity: HLA-DRReactivity: Human, African Green Monkey, Baboon, Chimpanzee, Cynomolgus Monkey, Dog, Common Marmoset, Rhesus Macaque, Squirrel MonkeyFormat: cFluor® R780Isotype: Mouse IgG2a, kTested Dilution: 5 µl/TestApplication: Flow CytometryStorage: 2-8°C protected from light. Do not freezeFormulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA)Data Sheets: TDS | SDS RECOMMENDED USAGEEach lot of this antibody is quality control tested using flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 μL per 1 million cells in a staining volume of 100 μL. If whole blood is analyzed, then use 5 μL per 100 μL. It is recommended that users titrate the antibody to obtain the optimal result for their specific application. Please briefly centrifuge the reagent vial before use. Use appropriate personal protective equipment per the product safety data sheet when using this product. REFERENCES Knapp W. 1989. Leucocyte Typing IV. Oxford University Press New York. Barclay N, et al. 1997. The Leucocyte …
brand: Cytek Biosciences
sku: R7-21621
additional property: Size
  type: PropertyValue
  value: 100 Tests, 25 Tests
offers: AggregateOffer
  low price: 176.00
  high price: 347.00
  price currency: USD
  offer count: 2
  offers: Offer
    price: 347.00
    price currency: USD
    availability: https://schema.org/InStock
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    sku: R7-21621
  offers: Offer
    price: 176.00
    price currency: USD
    availability: https://schema.org/InStock
    item condition: https://schema.org/NewCondition
    sku: R7-21622

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