CD206 Recombinant Rabbit mAb (S-3477-27)

Product Specification Host Rabbit Antigen CD206 Synonyms Macrophage mannose receptor 1; MMR; Mrc1 Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession Q61830 Clone Number S-3477-27 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC-P Reactivity Hu, Ms, Rt Positive Sample PMA, IL-4 and Brefeldin A treated THP-1, mouse liver, mouse lung, mouse spleen, rat liver, rat lung, rat spleen Purification Protein A Concentration 0.5 mg/ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied Dilution application dilution species WB 1:1000 Hu, Ms, Rt IHC-P 1:2000-1:5000 Hu, Ms, Rt BackgroundCD206, also known as the mannose receptor (MR) or mannose receptor C type 1 (MRC1), is a transmembrane glycoprotein that belongs to the C-type lectin family. It is predominantly expressed by tissue macrophages, dendritic cells, and certain lymphatic or liver endothelial cells. CD206 recognizes and mediates endocytosis of pathogens by binding to glycoproteins terminated with mannose. This receptor serves as a homeostatic receptor by binding and scavenging unwanted high mannose N-linked glycoproteins as well as pituitary hormones from the circulation. In addition, CD206 is a marker for the M2 phenotype of macrophages, which are involved in immunosuppression, tissue remodeling, and Th2 effector responses. Its expression is regulated by various cytokines and is considered a marker of an M2-like macrophage phenotype.