Recombinant Human Heregulin beta1 Protein, Active

Product Overview Product Name Recombinant Human Heregulin beta1 Protein Target Symbol NRG1 Alternative Names Neuregulin1 beta 1, Neuregulin1 b1, Heregulin, Heregulin b1, Acetylcholine receptor inducing activity, ARIA, Breast cancer cell differentiation factor p45, GGF, GGF2, Glial Growth Factor, HGL, HRG, HRG beta 1, HRG1, NDF, Neu Differentiation Factor, Neuregulin 1, NRG1, SMDF, Sensory and Motor Neuron Derived Factor Accession Number Q02297 Expression System E. coli. Molecular Weight 7.5 kDa (predicted) Sequence Ser177-Glu241 Purity Determined by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining Activity Determined by in-house activity assay Formulation Lyophilized from sterile PBS with Trehalose, pH 7.4 Endotoxin Level Available Upon Request Shipping Shipped at ambient temperature. Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles. Reconstitution Reconstitute at 100 ug/mL in sterile PBS. Target Function Heregulin beta 1 (HRG-beta1), also named Neuregulin 1, plays a role in the development and function of the nervous system and heart. HRG-beta1 is also involved in the development and maintenance of synapses including the regulation of neurotransmitters and the branching morphogenesis of mammary glands. Signaling occurs with HRG-beta1 binding to either ErbB3 (Her3) or ErbB4 (Her4), which promotes recruitment of ErbB2 (Her2) and signal transduction through the MAPK and phosphatidylinositol-3 kinase (PI3K) pathways. Tissue Specificity HRG-beta1 expression has been identified in brain, spinal cord, neurons, glial cells, peripheral nerves, heart, mammary gland, skin, lungs, kidneys ovaries and testes. Cellular Localization Membrane-bound and cleaved soluble protein forms Involvement In Disease Dysregulation of HRG-beta1 is associated with cardiac hypertrophy, diabetic neuropathy, Charcot-Marie-Tooth disease, Alzheimer’s disease, multiple sclerosis (MS), metabolic syndrome, obesity, schizophrenia, and various cancers (breast, prostate, colorectal, non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and ovarian).