PT-141

PT-141 is bremelanotide, a synthetic cyclic heptapeptide and melanocortin receptor agonist. [1] It’s supplied as lyophilized powder in a sealed vial. Our PT-141 has ≥99% purity, comes with HPLC and MS verification, and has a published COA. Anyone looking to buy PT-141 for research needs to know that PT-141 is the only compound in this product range with an FDA-approved counterpart, marketed as Vyleesi. This vial is not that product. It’s for research use only. PT-141 was derived from Melanotan II (an alpha-MSH analog developed for tanning). During Melanotan II research, consistent pro-arousal effects were observed [2], and bremelanotide was developed to isolate that activity while reducing the tanning (MC1R) effect. It acts on the central nervous system, not on peripheral blood flow. [3] MC4R activation in hypothalamic regions modulates dopaminergic and related signaling involved in arousal. [4] This is a CNS/neural pathway, distinct from the peripheral vascular mechanism of PDE5 inhibitors.