Prucalopride 1mg and 2mg tablets

Selective 5-HT4 receptor agonist that directly stimulates gut motility, licensed for chronic idiopathic constipation in adults where conventional laxatives haven’t provided adequate relief Different mechanism from bulk-forming, osmotic, or stimulant laxatives — restores normal peristaltic patterns through receptor-mediated action rather than softening stool or triggering single evacuations Standard adult dose is 2mg once daily, with 1mg once daily reserved for elderly patients (over 65), severe renal impairment (CrCl under 30 ml/min), or severe hepatic impairment (Child-Pugh C) Step-up option after conventional laxatives from at least two different classes have been tried at adequate doses for sufficient duration (typically 6 months). Prescriber assessment before supply is essential Strength 1mg and 2mg Pack size of 28 tablets