Dopamine receptor D5 (DRD5 or DRD1B) antibody

Anti-Dopamine receptor D5 (DRD5 or DRD1B) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). There are five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3, and D4 receptors are members of the D2-like family. Dopamine receptor D5, also known as DRD1B, is encoded by the DRD5 gene in human. D5 receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the D1 receptor. Both D5 and D1 receptors activate adenylyl cyclase. D1 receptor stimulates monophasic dose-dependent accumulation of cAMP in response to dopamine, while D5 receptor stimulates biphasic accumulation of cAMP under the same condition.